ACETONE | Occupational Safety and Health Administration

ACETONE†

Chemical Identification
CAS #	67-64-1
Formula	C₃H₆O
Synonyms	dimethyl ketone; ketone propane; 2-propanone

Physical Properties
Physical description	Colorless liquid with a fragrant, mint-like odor.
Boiling point	133°F	Molecular weight	58.1
Freezing point/melting point	-137°F	Vapor pressure	180 mmHg
Flash point	0°F	Vapor density
Specific gravity	0.791	Ionization potential	9.69 eV
Lower explosive limit (LEL)	2.5%	Upper explosive limit (UEL)	12.8%
NFPA health rating	1	NFPA fire rating	3
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0040
Sampling group
Sampler/Sampling media	ORBO™ 91 Carbosieve® S-III (130/65) [Supelco 20360]
Sampling time^*	60 min
Sampling volume (TWA)^*	3 L
Sampling flow rate (TWA)^*	0.05 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-FID
Method reference	OSHA 69 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Sampler/Sampling media

Bulk Method
Bulk Method

On-Site Screening Techniques
Device	CMS Chip	Detector tube
Model/Type	Acetone, 40-600 ppm range	Gastec 151
Sampling information (see manufacturer instructions)		0.05-2%

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA	1000 ppm (2400 mg/m³)	REL-TWA	250 ppm (590 mg/m³)	TLV-TWA	250 ppm [2014]	PEL-TWA	500 ppm (1200 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL	500 ppm [2014]	PEL-STEL	750 ppm (1780 mg/m³)
PEL-C		REL-C		TLV-C		PEL-C	3000 ppm
Skin notation	N	Skin notation	N	Skin notation	N	Skin notation	N
Notes: See 29 CFR 1910.1000 Table Z-1.		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH	2500 ppm (10% LEL)
Carcinogenic classifications: TLV-A4, EPA-I		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Acetone

NIOSH: Pocket Guide to Chemical Hazards - Acetone

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Acetone. See annual publication for most recent information.
ATSDR: Toxicological Profile for Acetone. June 2022.
Dietz, DD, Leininger, JR, Rauckman, EJ, et al.: Toxicity studies of acetone administered in the drinking water of rodents. Fund. Appl. Toxicol. 17:347-360, 1991.
EPA: Integrated Risk Information System - Acetone (CASRN 67-64-1). 2003.
NIOSH: Criteria for a Recommended Standard - Occupational Exposure to Ketones. June 1978.
NIOSH: Occupational Health Guideline for Acetone. 1988.
Wysocki, C.J., Dalton, P., Brody, M.J. and Lawley, H.J.: Acetone odor and irritation thresholds obtained from acetone-exposed factory workers and from control (occupationally unexposed) subjects. Am. Ind. Hyg. Assoc. J. 58(10): 704-711, 1997.

Last Updated Date : 12/22/2022