ACETONE†

Chemical Identification
Chemical Identification
CAS # 67-64-1
Formula

C₃H₆O

Synonyms

dimethyl ketone; ketone propane; 2-propanone

Physical Properties
Physical Properties
Physical description Colorless liquid with a fragrant, mint-like odor.
Boiling point 133°F Molecular weight 58.1
Freezing point/melting point -137°F Vapor pressure 180 mmHg
Flash point 0°F Vapor density
Specific gravity 0.791 Ionization potential 9.69 eV
Lower explosive limit (LEL) 2.5% Upper explosive limit (UEL) 12.8%
NFPA health rating 1 NFPA fire rating 3
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0040 0040
Sampling group
Sampler/Sampling media ORBO™ 91 Carbosieve® S-III (130/65) [Supelco 20360]
Sampling time*

60 min

60 min

Sampling volume (TWA)*

3 L

3 L

Sampling flow rate (TWA)*

0.05 L/min

0.05 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID GC-FID
Method reference OSHA 69 (fully validated) OSHA 69 modified NIOSH 1300 (fully validated)
Notes

For temporary use while ORBO 91 is unavailable, using NIOSH 1300 as evidence in media validity.

Do not sample more than 3 L.

Special requirements

After sampling, cap the samplers and pack securely for shipment.

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device CMS Chip Detector tube
Model/Type Acetone, 40-600 ppm range Gastec 151
Sampling information
(see manufacturer instructions)
0.05-2%
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

1000 ppm (2400 mg/m³)

REL-TWA

250 ppm (590 mg/m³)

TLV-TWA

250 ppm [2014]

PEL-TWA

500 ppm (1200 mg/m³)

PEL-STEL REL-STEL TLV-STEL

500 ppm [2014]

PEL-STEL

750 ppm (1780 mg/m³)

PEL-C REL-C TLV-C PEL-C

3000 ppm

Skin notation

N

Skin notation

N

Skin notation

N

Skin notation

N

Notes:

See 29 CFR 1910.1000 Table Z-1.

Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH

2500 ppm (10% LEL)

Carcinogenic classifications: TLV-A4, EPA-I Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Acetone

NIOSH: Pocket Guide to Chemical Hazards - Acetone

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Acetone. See annual publication for most recent information.
  • ATSDR: Toxicological Profile for Acetone. June 2022.
  • Dietz, DD, Leininger, JR, Rauckman, EJ, et al.: Toxicity studies of acetone administered in the drinking water of rodents. Fund. Appl. Toxicol. 17:347-360, 1991.
  • EPA: Integrated Risk Information System - Acetone (CASRN 67-64-1). 2003.
  • NIOSH: Criteria for a Recommended Standard - Occupational Exposure to Ketones. June 1978.
  • NIOSH: Occupational Health Guideline for Acetone. 1988.
  • Wysocki, C.J., Dalton, P., Brody, M.J. and Lawley, H.J.: Acetone odor and irritation thresholds obtained from acetone-exposed factory workers and from control (occupationally unexposed) subjects. Am. Ind. Hyg. Assoc. J. 58(10): 704-711, 1997.

Last Updated Date : 07/08/2022