1. OSHA Occupational Chemical Database
  2. EPICHLOROHYDRIN (1-CHLORO-2,3-EPOXYPROPANE)
Label abbreviations descriptions

EPICHLOROHYDRIN (1-CHLORO-2,3-EPOXYPROPANE)†

Chemical Identification
Chemical Identification
CAS # 106-89-8
Formula
 

C₃H₅ClO
Synonyms
 

2-chloropropylene oxide; β-chloropropylene oxide; 1-chloro-2,3-epoxypropane
Physical Properties
Physical Properties
Physical description Colorless liquid with a slightly irritating, chloroform-like odor.
Boiling point 242°F Molecular weight 92.5
Freezing point/melting point -54°F Vapor pressure 13 mmHg
Flash point 93°F Vapor density 3.29
Specific gravity 1.18 Ionization potential 10.60 eV
Lower explosive limit (LEL) 3.8% Upper explosive limit (UEL) 21%
NFPA health rating 4 NFPA fire rating 3
NFPA reactivity rating 2 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0645
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
 

480 min
Sampling volume (TWA)*
 

2-30 L
Sampling flow rate (TWA)*
 

0.01-0.2 L/min
Sampling volume (STEL/Peak/C)*
 

 
Sampling flow rate (STEL/Peak/C)*
 

 
Analytical method instruments GC-FID
Method reference NIOSH 1010 (fully validated)
Notes
 

 
Special requirements
 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

Wipe with charcoal pad, seal in glass vial for shipment. [3M 3500]
Bulk Method
Bulk Method
 

 
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

5 ppm (19 mg/m³)

 REL-TWA
 

 

 TLV-TWA
 

0.5 ppm [1994]

 PEL-TWA
 

0.05 ppm (0.19 mg/m³)
PEL-STEL
 

 

 REL-STEL
 

 

 TLV-STEL
 

 

 PEL-STEL
 

 
PEL-C
 

 

 REL-C
 

 

 TLV-C
 

 

 PEL-C
 

 
Skin notation
 

Y

 Skin notation
 

N

 Skin notation
 

Y

 Skin notation
 

Y
Notes:
 

See 29 CFR 1910.1000 Table Z-1.

 Notes:
 

CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION (LOQ 2.5 mg/m3). See Appendix A.

 Notes:
 

 

 Notes:
 

 
Health factors:  See NIH-NLM PubChem. IDLH
 

75 ppm
Carcinogenic classifications: IARC-2A, NIOSH-Ca, NTP-R, TLV-A3, EPA-B2 Notes:
 

Ca
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

5 ppm/20 ppm/100 ppm
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - 1-Chloro-2,3-epoxypropane

NIOSH: Pocket Guide to Chemical Hazards - Epichlorohydrin

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Epichlorohydrin. See annual publication for most recent information.
  • U.S. EPA Integrated Risk Information System: Epichlorohydrin (CASRN 106-89-8).
  • De Rooij, B.M., Commandeur, J.N., Ramcharan, J.R., Schuilenburg, H.C., Van Baar, B.L. and Vermeulen, N.P.: Identification and quantitative determination of 3-chloro-2-hydroxypropylmercapturic acid and ⍺-chlorohydrin in urine of rats treated with epichlorohydrin. J. Chromatogr. B Biomed. Appl. 685(2): 241-250, 1996.
  • Hindsø Landin, H., Grummt, T. Laurent, C. and Tates, A.: Monitoring of occupational exposure to epichlorohydrin by genetic effects and hemoglobin adducts. Mutat. Res. 381(2): 217-226, 1997.
  • Luo, J.-C., Cheng, T.-J., Kuo, H.-W. and Chang, M.J.W.: Decreased lung function associated with occupational exposure to epichlorohydrin and the modification effects of glutathione S-transferase polymorphisms. J. Occup. Environ. Med. 46(3): 280-286, 2004.
  • Mazzullo, M., Colacci, A., Grilli, S., Prodi, G. and Arfellini, G.: In vivo and in vitro binding of epichlorohydrin to nucleic acids. Cancer Lett. 23(1): 81-90, 1984.
  • No Author: Epichlorohydrin. Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • Pohanish, R.P. (editor): Epichlorohydrin. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1015-1017.

Last Updated Date : 12/28/2020