N-NITROSODIMETHYLAMINE‡

Chemical Identification
Chemical Identification
CAS # 62-75-9
Formula

C₂H₆N₂O

Synonyms

dimethylnitrosamine; N,N-dimethylnitrosamine; DMNA; N-methyl-N-nitroso-methanamine; NDMA; N-nitroso-N,N-dimethylamine, nitrosodimethylamine

Physical Properties
Physical Properties
Physical description Yellow, oily liquid with a faint characteristic odor.
Boiling point 306°F Molecular weight 74.1
Freezing point/melting point Vapor pressure 3 mmHg
Flash point 142°F Vapor density 2.56
Specific gravity 1.005 Ionization potential 8.69 eV
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1942
Sampling group
Sampler/Sampling media ThermoSorb/N air sampler [No longer available]
Sampling time*

75 min

Sampling volume (TWA)*

75 L

Sampling flow rate (TWA)*

1 L/min

Sampling volume (STEL/Peak/C)*
 

 

Sampling flow rate (STEL/Peak/C)*
 

 

Analytical method instruments GC-TEA
Method reference OSHA 27 (fully validated)
Notes
 

This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-4900.

Special requirements
 

Store samples in freezer.

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

REL-TWA
 

 

TLV-TWA
 

 

PEL-TWA
 

 

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

 

PEL-STEL
 

 

PEL-C
 

 

REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation
 

N

Skin notation
 

N

Skin notation
 

Y

Skin notation
 

N

Notes:
 

See 29 CFR 1910.1016, N-Nitrosodimethylamine (requirements identical to29 CFR 1910.1003, 13 Carcinogens).

Notes:
 

CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION. See Appendix A, NIOSH Potential Occupational Carcinogens.

Notes:
 

Exposure by all routes should be carefully controlled to levels as low as possible. [1992]

Notes:
 

See California Code of Regulations, Title 8, Section 5209. Carcinogens.

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: IARC-2A, NIOSH-Ca, NTP-R, OSHA-Ca, TLV-A3, EPA-B2 Notes:
 

Ca

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosodimethylamine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosodimethylamine

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - N-Nitrosodimethylamine. See annual publication for most recent information.
  • EPA Air Toxics Website: N-Nitrosodimethylamine. U.S. Environmental Protection Agency Technology Transfer Network.
  • Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profile for N-nitrosodimethylamine. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, 1989.
  • California Department of Health Services: NDMA and Other Nitrosamines - Drinking Water Issues.
  • Choi, J. and Valentine, R.L.: Formation of N-nitrosodimethylamine (NDMA) from reaction of monochloramine: a new disinfection by-product. Water Res. 36(4): 817,824, 2002.
  • Lin, H.L., Parsels, L.A., Maybaum, J. and Hollenberg, P.F.: N-Nitrosodimethylamine-mediated cytotoxicity in a cell line expressing P450 2E1: evidence for apoptic cell death. Toxicol. Appl. Pharmacol. 157(2): 117-124, 1999.
  • Mitch, W.A., Gerecke, A.C. and Sedlak, D.L.: A N-nitrosodimethylamine precursor analysis for chlorination of water and wastewater. Water Res. 37(15): 3733-3741, 2003.
  • Niot-Mansart, V., Muhamedi, A. and Arnould, J.P.: A competitive ELISA detecting 7-methylguanosine adduct induced by N-nitrosodimethylamine exposure. Hum. Exp. Toxicol. 24(2): 89-94, 2005.
  • No Author: Nitrosamines, 15 Listings. Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • Oury, B., Limasset, J.C. and Protois, J.C.: Assessment of exposure to carcinogenic N-nitrosamines in the rubber industry. Int. Arch. Occup. Environ. Health 70(4): 261-271, 1997.
  • Pohanish, R.P. (editor): N-Nitrosodimethylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1731-1733.
  • Siddiqui, M. and Atasi, K.Z.: N-Nitrosodimethylamine: a disinfectant byproduct and its occurrence in wastewater. Water Environ. Res. 76(4): 316-326, 2004.
  • Straif, K., et al.: Exposure to high concentrations of nitrosamines and cancer mortality among a cohort of rubber workers. Occup. Environ. Med. 57(3): 180-187, 2000.

Last Updated Date : 01/28/2021