N-NITROSODIMETHYLAMINE | Occupational Safety and Health Administration

Chemical Identification
CAS #	62-75-9
Formula	C₂H₆N₂O
Synonyms	dimethylnitrosamine; N,N-dimethylnitrosamine; DMNA; N-methyl-N-nitroso-methanamine; NDMA; N-nitroso-N,N-dimethylamine, nitrosodimethylamine

Physical Properties
Physical description	Yellow, oily liquid with a faint characteristic odor.
Boiling point	306°F	Molecular weight	74.1
Freezing point/melting point		Vapor pressure	3 mmHg
Flash point	142°F	Vapor density	2.56
Specific gravity	1.005	Ionization potential	8.69 eV
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1942
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*	75 min
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 27 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	N	Skin notation	N	Skin notation	Y	Skin notation	N
Notes: See 29 CFR 1910.1016, N-Nitrosodimethylamine (requirements identical to29 CFR 1910.1003, 13 Carcinogens).		Notes: CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION. See Appendix A, NIOSH Potential Occupational Carcinogens.		Notes: Exposure by all routes should be carefully controlled to levels as low as possible. [1992]		Notes: See California Code of Regulations, Title 8, Section 5209. Carcinogens.
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-2A, NIOSH-Ca, NTP-R, OSHA-Ca, TLV-A3, EPA-B2		Notes: Ca
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosodimethylamine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosodimethylamine

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - N-Nitrosodimethylamine. See annual publication for most recent information.
EPA Air Toxics Website: N-Nitrosodimethylamine. U.S. Environmental Protection Agency Technology Transfer Network.
Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profile for N-nitrosodimethylamine. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, 1989.
California Department of Health Services: NDMA and Other Nitrosamines - Drinking Water Issues.
Choi, J. and Valentine, R.L.: Formation of N-nitrosodimethylamine (NDMA) from reaction of monochloramine: a new disinfection by-product. Water Res. 36(4): 817,824, 2002.
Lin, H.L., Parsels, L.A., Maybaum, J. and Hollenberg, P.F.: N-Nitrosodimethylamine-mediated cytotoxicity in a cell line expressing P450 2E1: evidence for apoptic cell death. Toxicol. Appl. Pharmacol. 157(2): 117-124, 1999.
Mitch, W.A., Gerecke, A.C. and Sedlak, D.L.: A N-nitrosodimethylamine precursor analysis for chlorination of water and wastewater. Water Res. 37(15): 3733-3741, 2003.
Niot-Mansart, V., Muhamedi, A. and Arnould, J.P.: A competitive ELISA detecting 7-methylguanosine adduct induced by N-nitrosodimethylamine exposure. Hum. Exp. Toxicol. 24(2): 89-94, 2005.
No Author: Nitrosamines, 15 Listings. Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Oury, B., Limasset, J.C. and Protois, J.C.: Assessment of exposure to carcinogenic N-nitrosamines in the rubber industry. Int. Arch. Occup. Environ. Health 70(4): 261-271, 1997.
Pohanish, R.P. (editor): N-Nitrosodimethylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1731-1733.
Siddiqui, M. and Atasi, K.Z.: N-Nitrosodimethylamine: a disinfectant byproduct and its occurrence in wastewater. Water Environ. Res. 76(4): 316-326, 2004.
Straif, K., et al.: Exposure to high concentrations of nitrosamines and cancer mortality among a cohort of rubber workers. Occup. Environ. Med. 57(3): 180-187, 2000.

N-NITROSODIMETHYLAMINE‡

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References