ETHYL ETHER (DIETHYL ETHER)†

Chemical Identification
Chemical Identification
CAS # 60-29-7
Formula

C₄H₁₀O

Synonyms

diethyl ether; diethyl oxide; ethyl oxide; ether; solvent ether

Physical Properties
Physical Properties
Physical description Colorless liquid with a pungent, sweetish odor.
Boiling point 94°F Molecular weight 74.1
Freezing point/melting point -177°F Vapor pressure 440 mmHg
Flash point -49°F Vapor density 2.6
Specific gravity 0.71 Ionization potential 9.53 eV
Lower explosive limit (LEL) 1.9% Upper explosive limit (UEL) 36%
NFPA health rating 1 NFPA fire rating 4
NFPA reactivity rating 1 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1210
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
Sampling volume (TWA)*

0.25-3 L

Sampling flow rate (TWA)*
 

0.01-0.2 L/min

Sampling volume (STEL/Peak/C)*
 

 

Sampling flow rate (STEL/Peak/C)*
 

 

Analytical method instruments GC-FID
Method reference NIOSH 1610 (partially validated)
Notes
 

 

Special requirements
 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

400 ppm (1200 mg/m³)

REL-TWA
 

 

TLV-TWA
 

400 ppm [1966]

PEL-TWA
 

400 ppm (1200 mg/m³)

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

500 ppm [1966]

PEL-STEL
 

500 ppm (1500 mg/m³)

PEL-C
 

 

REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation
 

N

Skin notation
 

N

Skin notation
 

N

Skin notation
 

N

Notes:
 

See 29 CFR 1910.1000 Table Z-1.

Notes:
 

See Appendix D - Substances with No Established RELs.

Notes:
 

 

Notes:
 

 

Health factors:  See NIH-NLM PubChem. IDLH
 

1900 ppm

Carcinogenic classifications: Not listed Notes:
 

10% of LEL

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Diethyl ether

NIOSH: Pocket Guide to Chemical Hazards - Ethyl ether

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Ethyl ether. See annual publication for most recent information.
  • Bell, C.M., Gutowski, S.J., Young, S. and Wells, D.: Diethyl ether interference with infrared breath analysis. J. Anal. Toxicol. 16(3): 166-168, 1992.
  • Brady, J.F., Lee, M.J., Li, M., Ishizaki, H. and Yang, C.S.: Diethyl ether as a substrate for acetone/ethanol-inducible cytochrome P-450 and as an inducer for cytochrome(s) P-450. Mol. Pharmacol. 33(2): 148-154, 1988.
  • Eger, E.I., 2nd, Laster, M.J., Gregory, G.A., Katoh, T. and Sonner, J.M.: Women appear to have the same minimum alveolar concentration as men: a retrospective study. Anesthesiology 99(5): 1059-1061, 2003.
  • Krenz, S., Zimmermann, G., Kolly, S. and Zullino, D.F.: Ether: a forgotten addiction. Addiction 98(8): 1167-1168, 2003.
  • Pohanish, R.P. (editor): Ethyl ether. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1104-1106.

Last Updated Date : 12/28/2020