GLYCIDOL(2,3-EPOXY-1-PROPANOL)†

Chemical Identification
Chemical Identification
CAS # 556-52-5
Formula

C₃H₆O₂

Synonyms
 

2,3-epoxy-1-propanol; epoxypropyl alcohol; glycide; hydroxymethyl ethylene oxide; 2-hydroxymethyl oxiran; 3-hydroxypropylene oxide

Physical Properties
Physical Properties
Physical description Colorless, odorless liquid.
Boiling point 320°F (decomposes) Molecular weight 74.1
Freezing point/melting point -49°F Vapor pressure 0.9 mmHg at 77°F
Flash point 162°F Vapor density 2.15
Specific gravity 1.12 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1365
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
 

 

Sampling volume (TWA)*
 

5-100 L

Sampling flow rate (TWA)*
 

0.01-1 L/min

Sampling volume (STEL/Peak/C)*
 

 

Sampling flow rate (STEL/Peak/C)*
 

 

Analytical method instruments GC-FID
Method reference NIOSH 1608 (fully validated)
Notes
 

Submit as a separate sample. Refrigerate   samples at 4°C immediately and ship on ice to prevent low recoveries. Analyze samples as soon as possible.

Special requirements
 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

50 ppm (150 mg/m³)

REL-TWA
 

25 ppm (75 mg/m³)

TLV-TWA
 

2 ppm [1993]

PEL-TWA
 

2 ppm (6.1 mg/m³)

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

 

PEL-STEL
 

 

PEL-C
 

 

REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation
 

N

Skin notation
 

N

Skin notation
 

N

Skin notation
 

N

Notes:
 

See 29 CFR 1910.1000 Table Z-1.

Notes:
 

 

Notes:
 

 

Notes:
 

 

Health factors:  See NIH-NLM PubChem. IDLH
 

150 ppm

Carcinogenic classifications: NTP-R, TLV-A3, IARC-2A Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Glycidol

NIOSH: Pocket Guide to Chemical Hazards - Glycidol

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Glycidol. See annual publication for most recent information.
  • No Author: Glycidol . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • NTP: NTP toxicology and carcinogenesis studies of glycidol (CAS No. 556-52-5) in F344/N rats and B6C3F1 mice (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser. 374: 1-229, 1990.
  • Guo, T.L., et al.: Glycidol modulation of the immune responses in female B6C3F1 mice. Drug Chem. Toxicol. 23(3): 433-457, 2000.
  • Nomeir, A.A., et al.: Comparative disposition of 2,3-epoxy-1-propanol (glycidol) in rats following oral and intravenous administration. J. Toxicol. Environ. Health 44(2): 203-217, 1995.
  • Pohanish, R.P. (editor): Glycidol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1210-1212.
  • Sills, R.C., Hailey, J.R., Neal, J., Boorman, G.A., Haseman, J.K. and Melnick, R.L.: Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. Toxicol. Pathol. 27(5): 589-599, 1999.
  • Yamamoto, M., Horiuchi, M., Ishiguro, N., Shinagawa, M., Matsuo, T. and Keneko, K.: Glycidol degrades scrapie mouse prion protein. J. Vet. Med. Sci. 63(9): 983-990, 2001.

Last Updated Date : 01/28/2021