BIS(CHLOROMETHYL) ETHER‡

Chemical Identification
Chemical Identification
CAS # 542-88-1
Formula

C₂H₄Cl₂O

Synonyms

BCME; bis-CME; chloromethyl ether; dichlorodimethyl ether; dichloromethyl ether; oxybis(chloromethane)

Physical Properties
Physical Properties
Physical description Colorless liquid with a suffocating odor.
Boiling point 223°F Molecular weight 115
Freezing point/melting point -43°F Vapor pressure 30 mmHg at 72°F
Flash point <66°F Vapor density
Specific gravity 1.32 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating 4 NFPA fire rating 3
NFPA reactivity rating 1 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 2630
Sampling group
Sampler/Sampling media Midget fritted glass bubbler (MFGB) containing 10 mL (Derivatizing reagent: 2,4,6-Trichlorophenol/Sodium methoxide) [Infrequently Requested Method - OSHA staff please contact SLTC before sampling 801-233-4900]
Sampling time*
Sampling volume (TWA)*

50 L

Sampling flow rate (TWA)*

0.5 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-ECD
Method reference OSHA 10 (fully validated)
Notes

Derivatizing reagent: 16 grams of 2,4,6-Trichlorophenol and 4.4 grams of Sodium Methoxide dissolved in 1 Liter of Methanol.

OSHA personnel may obtain sampling solution from the SLTC.

 

Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

Ca

REL-TWA TLV-TWA

0.001 ppm [1979]

PEL-TWA
PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

N

Skin notation

N

Skin notation

N

Skin notation

N

Notes:

See 29 CFR 1910.1003, 13 Carcinogens.

Notes:

CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION. See Appendix A and Appendix B - 13 OSHA-regulated carcinogens.

Notes: Notes:

See California Code of Regulations, Title 8, Section 5209. Carcinogens.

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: IARC-1, NIOSH-Ca, NTP-K, OSHA-Ca, TLV-A1, EPA-A Notes:

Ca

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

--/0.1 ppm/0.5 ppm

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Dichlorodimethyl ether, symmetrical

NIOSH: Pocket Guide to Chemical Hazards - bis-Chloromethyl ether

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - bis(Chloromethyl) ether. See annual publication for most recent information.
  • EPA Air Toxics Website: bis(Chloromethyl)ether (BCME). U.S. Environmental Protection Agency Technology Transfer Network.
  • No Author: bis(Chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether (CAS Nos. 542-88-1 and 107-30-2). Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • Pohanish, R.P. (editor): Bis(Chloromethyl) Ether. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 345-348.
  • Weiss, W. and Nash, D.: An epidemic of lung cancer due to chloromethyl ethers. 30 years of observation. J. Occup. Environ. Med. 39(10): 1003-1009, 1997.

Last Updated Date : 12/17/2020