DISULFOTON

Chemical Identification
Chemical Identification
CAS # 298-04-4
Formula

C₈H₁₉O₂PS₃

Synonyms

o,o-diethyl S-2-(ethylthio)-ethyl phosphorodithioate; Di-Syston®; thiodemeton; phosphorodithioic acid

Physical Properties
Physical Properties
Physical description Oily, colorless to yellow liquid with a characteristic, sulfur odor.
Boiling point 270-271°F Molecular weight 274.4
Freezing point/melting point -13°F Vapor pressure 0.0002 mmHg
Flash point >180°F Vapor density
Specific gravity 1.14 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 2680
Sampling group
Sampler/Sampling media OSHA versatile sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg) with GFF enclosed [SKC 226-30-16]
Sampling time*
Sampling volume (TWA)*

480 L

Sampling flow rate (TWA)*

1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FPD
Method reference OSHA PV2105 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media

Wipe with GFF (37 mm), Type A/E [AP4003705]

Bulk Method
Bulk Method

Limit the amount of bulk submitted to 1 g or 1 mL.

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA

0.1 mg/m³

TLV-TWA

0.05 mg/m³ (inhalable fraction and vapor) [2000]

PEL-TWA

0.1 mg/m³

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

NA

Skin notation

N

Skin notation

Y

Skin notation

Y

Notes:

Not established

Notes: Notes:

BEI®

Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: TLV-A4 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Disulfoton

NIOSH: Pocket Guide to Chemical Hazards - Disulfoton

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Disulfoton. See annual publication for most recent information.
  • US EPA Integrated Risk Information System: Disulfoton (CASRN 298-04-4).
  • Henderson, M.C., Krueger, S.K., Siddens, L.K., Stevens, J.F. and Williams, D.E.: S-oxygenation of the thioether organohosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2. Biochem. Pharmacol. 68(5): 959-967, 2004.
  • Pohanish, R.P. (editor): Disulfoton. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 991-993.
  • Usmani, K.A., Karoly, E.D., Hodgson, E. and Rose, R.L.: In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C family. Drug Metab. Dispos. 32(3): 333-339, 2004.

Last Updated Date : 12/28/2020