1. OSHA Occupational Chemical Database
  2. HALOTHANE
Label abbreviations descriptions

HALOTHANE

Chemical Identification
Chemical Identification
CAS # 151-67-7
Formula

F₃CCHBrCl
Synonyms

1-bromo-1-chloro-2,2,2-trifluoroethane; 2-bromo-2-chloro-1,1,1-trifluoroethane; 1,1,1-trifluoro-2-bromo-2-chloroethane; 2,2,2-trifluoro-1-bromo-1-chloroethane
Physical Properties
Physical Properties
Physical description Clear, colorless liquid with a sweetish, pleasant odor.
Boiling point 122.4°F Molecular weight 197.4
Freezing point/melting point -180°F Vapor pressure 243 mmHg
Flash point Vapor density 6.8
Specific gravity 1.87 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0395
Sampling group
Sampler/Sampling media Anasorb 747 (140/70 mg) [SKC 226-81A]
Sampling time*

240 min
Sampling volume (TWA)*

12 L
Sampling flow rate (TWA)*

0.05 L/min
Sampling volume (STEL/Peak/C)*

0.75 L
Sampling flow rate (STEL/Peak/C)*

0.05 L/min
Analytical method instruments GC-FID
Method reference OSHA 103 (fully validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA TLV-TWA

50 ppm [1979]

 PEL-TWA

2 ppm (16 mg/m³)
PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C

2 ppm (16.2 mg/m³) [60 minutes]

 TLV-C PEL-C
Skin notation

NA

 Skin notation

N

 Skin notation

N

 Skin notation

N
Notes:

Not established

 Notes:

REL IS FOR EXPOSURE TO WASTE ANESTHETIC GASES

 Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: IARC-3, TLV-A4 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Halothane

NIOSH: Pocket Guide to Chemical Hazards - Halothane

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Halothane. See annual publication for most recent information.
  • Imbriani, M., Ghittori, S., Zadra, P. and Imberti, R.: Biological monitoring of the occupational exposure to halothane (fluothane) in operating room personnel. Am. J. Ind. Med. 20(1): 103-112, 1991.
  • Kenna, J.G., Satoh, H., Christ, D.D. and Pohl, L.R.: Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane. J. Pharmacol. Exp. Ther. 245(3): 1103-1109, 1988.
  • Njoku, D.B., et al.: Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists. Anesth. Analg. 94(2): 243-249, 2002.
  • Pohanish, R.P. (editor): Halothane. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1221-1223.
  • Sutherland, D.E. and Smith, W.A.: Chemical hepatitis associated with occupational exposure to halothane in a research laboratory. Vet. Hum. Toxicol. 34(5): 423-424, 1992.

Last Updated Date : 12/31/2020