HALOTHANE

Chemical Identification
CAS #	151-67-7
Formula	F₃CCHBrCl
Synonyms	1-bromo-1-chloro-2,2,2-trifluoroethane; 2-bromo-2-chloro-1,1,1-trifluoroethane; 1,1,1-trifluoro-2-bromo-2-chloroethane; 2,2,2-trifluoro-1-bromo-1-chloroethane

Physical Properties
Physical description	Clear, colorless liquid with a sweetish, pleasant odor.
Boiling point	122.4°F	Molecular weight	197.4
Freezing point/melting point	-180°F	Vapor pressure	243 mmHg
Flash point		Vapor density	6.8
Specific gravity	1.87	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	0395
Sampling group
Sampler/Sampling media	Anasorb 747 (140/70 mg) [SKC 226-81A]
Sampling time^*	240 min
Sampling volume (TWA)^*	12 L
Sampling flow rate (TWA)^*	0.05 L/min
Sampling volume (STEL/Peak/C)^*	0.75 L
Sampling flow rate (STEL/Peak/C)^*	0.05 L/min
Analytical method instruments	GC-FID
Method reference	OSHA 103 (fully validated)
Notes
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA	50 ppm [1979]	PEL-TWA	2 ppm (16 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C	2 ppm (16.2 mg/m³) [60 minutes]	TLV-C		PEL-C
Skin notation	NA	Skin notation	N	Skin notation	N	Skin notation	N
Notes: Not established		Notes: REL IS FOR EXPOSURE TO WASTE ANESTHETIC GASES		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: IARC-3, TLV-A4		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - Halothane

NIOSH: Pocket Guide to Chemical Hazards - Halothane

Literature References

ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Halothane. See annual publication for most recent information.
Imbriani, M., Ghittori, S., Zadra, P. and Imberti, R.: Biological monitoring of the occupational exposure to halothane (fluothane) in operating room personnel. Am. J. Ind. Med. 20(1): 103-112, 1991.
Kenna, J.G., Satoh, H., Christ, D.D. and Pohl, L.R.: Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane. J. Pharmacol. Exp. Ther. 245(3): 1103-1109, 1988.
Njoku, D.B., et al.: Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists. Anesth. Analg. 94(2): 243-249, 2002.
Pohanish, R.P. (editor): Halothane. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1221-1223.
Sutherland, D.E. and Smith, W.A.: Chemical hepatitis associated with occupational exposure to halothane in a research laboratory. Vet. Hum. Toxicol. 34(5): 423-424, 1992.

Last Updated Date : 12/31/2020

HALOTHANE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References