1. OSHA Occupational Chemical Database
  2. METHYLENEDIANILINE (4-4'-METHYLENEDIANILINE; MDA)
Label abbreviations descriptions

METHYLENEDIANILINE (4-4'-METHYLENEDIANILINE; MDA)‡

Chemical Identification
Chemical Identification
CAS # 101-77-9
Formula

C₁₃H₁₄N₂
Synonyms

4,4'-diaminodiphenylmethane; para, para'-diaminodiphenyl-methane; dianilinomethane; 4,4'-diphenylmethanediamine
Physical Properties
Physical Properties
Physical description Pale-brown, crystalline solid with a faint, amine-like odor.
Boiling point 748°F Molecular weight 198.3
Freezing point/melting point 198°F Vapor pressure 0.0000002 mmHg at 77°F
Flash point 430°F Vapor density 6.8
Specific gravity 1.15 Ionization potential 10.70 eV
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating 2 NFPA fire rating 1
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1732
Sampling group
Sampler/Sampling media 2 GFFs (37 mm) coated with sulfuric acid, in 3-piece cassette, separated by the ring section [SKC 225-9004]
Sampling time*

100 min
Sampling volume (TWA)*
 

100 L
Sampling flow rate (TWA)*
 

1 L/min
Sampling volume (STEL/Peak/C)*
 

 
Sampling flow rate (STEL/Peak/C)*
 

 
Analytical method instruments GC-ECD
Method reference OSHA 57 (fully validated)
Notes
 

Within 10 hours after sampling, transfer filters to glass vial containing 2 mL deionized water. 
Special requirements
 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

Wipe with GFFs wetted with 0.6 mL of a 60/40 methanol/deionized water solution. Wipe samples are placed in a solution of 0.07 N H₂SO₄ for shipment. Solutions of 60/40 methanol/deionized water and 0.07 N H₂SO₄ are available from the SLTC for OSHA staff. Kits for on-site screening of aromatic amines are available from commercial suppliers. [AP4003705]
Bulk Method
Bulk Method
 

 
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

10 ppb [5 ppb Action Level]

 REL-TWA
 

 

 TLV-TWA
 

0.1 ppm [1992]

 PEL-TWA
 

0.01 ppm (0.08 mg/m³)
PEL-STEL
 

100 ppb

 REL-STEL
 

 

 TLV-STEL
 

 

 PEL-STEL
 

0.1 ppm (0.8 mg/m³)
PEL-C
 

 

 REL-C
 

 

 TLV-C
 

 

 PEL-C
 

 
Skin notation
 

N

 Skin notation
 

N

 Skin notation
 

Y

 Skin notation
 

Y
Notes:
 

See 29 CFR 1910.1050, Methylenedianiline.

 Notes:
 

CARCINOGEN (Ca); REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION (LOQ 0.03 mg/m³). See Appendix A, NIOSH Potential Occupational Carcinogens.

 Notes:
 

 

 Notes:
 

See also California Code of Regulations, Title 8 §1535. Methylenedianiline. (Construction) and §5200. Methylenedianiline. (General Industry)
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: IARC-2B, NIOSH-Ca, NTP-R, OSHA-Ca, TLV-A3 Notes:
 

Ca
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - 4,4'-Diaminodiphenylmethane

NIOSH: Pocket Guide to Chemical Hazards - 4,4'-Methylenedianiline

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 4,4'-Methylene dianiline. See annual publication for most recent information.

Last Updated Date : 01/05/2021