DIMETHYLACETAMIDE†

Chemical Identification
Chemical Identification
CAS # 127-19-5
Formula

C₄H₉NO

Synonyms

N,N-dimethyl acetamide; DMAC; acetic acid dimethylamide

Physical Properties
Physical Properties
Physical description Colorless liquid with a weak, ammonia- or fish-like odor.
Boiling point 329°F Molecular weight 87.1
Freezing point/melting point -4°F Vapor pressure 2 mmHg
Flash point 158°F (open cup) Vapor density
Specific gravity 0.94 Ionization potential 8.81 eV
Lower explosive limit (LEL) 1.8% at 212°F Upper explosive limit (UEL) 11.5% at 320°F
NFPA health rating 2 NFPA fire rating 2
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0927
Sampling group
Sampler/Sampling media Silica gel tube (150/75 mg) [SKC 226-10]
Sampling time*
Sampling volume (TWA)*

80 L

Sampling flow rate (TWA)*

1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference NIOSH 2004 (fully validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

10 ppm (35 mg/m³)

REL-TWA

10 ppm (35 mg/m³)

TLV-TWA

10 ppm [2017]

PEL-TWA

10 ppm (35 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

Y

Skin notation

Y

Skin notation

Y

Skin notation

Y

Notes:

See 29 CFR 1910.1000 Table Z-1.

Notes: Notes:

BEI®

Notes:
Health factors:  See NIH-NLM PubChem. IDLH

300 ppm

Carcinogenic classifications: TLV-A3 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Dimethylacetamide

NIOSH: Pocket Guide to Chemical Hazards - Dimethyl acetamide

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Dimethylacetamide. See annual publication for most recent information.
  • Lee, C.-Y., Jung, S.-J., Kim, S.-A., Park, K.-S. and Ha, B.-G. Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers. Occup. Environ. Med. 63(10): 688-693, 2006.
  • Nimiyama, T., et al. Dermal absorption of N,N-dimethylacetamide in human volunteers. Int. Arch. Occup. Environ. Health 73(2): 121-126, 2000.
  • Okuda, H., et al. Developmental toxicity induced by inhalation exposure of pregnant rats to N,N-dimethylacetamide. J. Occup. Health 48(3): 154-160, 2006.
  • Perbellini, L., Princivalle, A., Caivano, M. and Montagnani, R. Biological monitoring of occupational exposure to N,N-dimethylacetamide with identification of a new metabolite. Occup. Environ. Med. 60(1): 746-751.
  • Pohanish, R.P. (editor) N,N-Dimethylacetamide. In Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 905-907.

Last Updated Date : 12/28/2020