β-CHLOROPRENE (2-CHLORO-1,3-BUTADIENE)†

Chemical Identification
Chemical Identification
CAS # 126-99-8
Formula

C₄H₅Cl

Synonyms

2-chloro-1,3-butadiene; chlorobutadiene; chloroprene

Physical Properties
Physical Properties
Physical description Colorless liquid with a pungent, ether-like odor.
Boiling point 139°F Molecular weight 88.5
Freezing point/melting point -153°F Vapor pressure 188 mmHg
Flash point -4°F Vapor density
Specific gravity 0.96 Ionization potential 8.79 eV
Lower explosive limit (LEL) 4.0% Upper explosive limit (UEL) 20.0%
NFPA health rating 2 NFPA fire rating 3
NFPA reactivity rating 1 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0680
Sampling group
Sampler/Sampling media Chromosorb® 106 (600/300 mg) [SKC 226-111A]
Sampling time*

120 min

Sampling volume (TWA)*

6 L

Sampling flow rate (TWA)*

0.05 L/min

Sampling volume (STEL/Peak/C)*

1.5 L

Sampling flow rate (STEL/Peak/C)*

0.1 L/min

Analytical method instruments GC-ECD
Method reference OSHA 112 (fully validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media

Wipe with charcoal pad, seal in glass vial for shipment. [3M 3500]

Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

25 ppm (90 mg/m³)

REL-TWA TLV-TWA

1 ppm [2016]

PEL-TWA

10 ppm (36 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C

1 ppm (3.6 mg/m³) [15 minute]

TLV-C PEL-C
Skin notation

Y

Skin notation

N

Skin notation

Y

Skin notation

NA

Notes:

See 29 CFR 1910.1000 Table Z-1.

Notes:

CARCINOGEN (Ca); See Appendix A

Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH

300 ppm

Carcinogenic classifications: EPA-L, IARC-2B, NIOSH-Ca, NTP-R; TLV-A2 Notes:

Ca

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Chloroprene, stabilized

NIOSH: Pocket Guide to Chemical Hazards - β-Chloroprene

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - β-Chloroprene. See annual publication for most recent information.
  • EPA Air Toxics Website: Chloroprene (2-Chloro-1,3-Butadiene). U.S. Environmental Protection Agency Technology Transfer Network.
  • Hurst, H.E. and Ali, M.Y.: Analyses of (1-chloroethenyl)oxirane headspace and hemoglobin N-valine adducts in erythrocytes indicate selective detoxification of (1-chloroethenyl)oxirane enantiomers. Chem. Biol. Interact. 166(1-3): 332-340, 2007.
  • Munter, T., Cottrell, L., Ghai, R., Golding, B.T. and Watson, W.P.: The metabolism and molecular toxicology of chloroprene. Chem. Biol. Interact. 166(1-3): 323-331, 2007.
  • No Author: Chloroprene. Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • Pohanish, R.P. (editor): Chloroprene. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 591-593.
  • Sanotskii, I.V.: Aspects of the toxicology of chloroprene: immediate and long-term effects. Environ. Health Perspect. 17: 85-93, 1976.
  • Valentine, R. and Himmelstein, M.W.: Overview of the acute, subchronic, reproductive, developmental and genetic toxicology of β-chloroprene. Chem. Biol. Interact. 135-136: 81-100, 2001.

Last Updated Date : 01/14/2021