DIETHANOLAMINE

Chemical Identification
Chemical Identification
CAS # 111-42-2
Formula

C₄H₁₁NO₂

Synonyms

DEA; di(2-hydroxyethyl)amine; 2,2'-dihydroxydiethyamine; diolamine; bis(2-hydroxyethyl)amine; 2,2'-iminodiethanol

Physical Properties
Physical Properties
Physical description Colorless crystals or a syrupy, white liquid (above 82°F) with a mild, ammonia-like odor.
Boiling point 516°F (decomposes) Molecular weight 105.2
Freezing point/melting point 82°F Vapor pressure <0.01 mmHg
Flash point 279°F Vapor density 3.65
Specific gravity 1.1 Ionization potential
Lower explosive limit (LEL) 1.6% Upper explosive limit (UEL) 9.8%
NFPA health rating 3 NFPA fire rating 1
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) D129
Sampling group
Sampler/Sampling media XAD-2 tube (80/40) coated with 10% 1-naphthylisothiocyanate (NITC) [SKC 226-30-18]
Sampling time*

100 min

Sampling volume (TWA)*

10 L

Sampling flow rate (TWA)*

0.1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments HPLC-UV
Method reference OSHA PV2018 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA

3 ppm (15 mg/m³)

TLV-TWA

1 mg/m³ (inhalable fraction and vapor) [2008]

PEL-TWA

0.46 ppm (2 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

NA

Skin notation

N

Skin notation

Y

Skin notation

Y

Notes:

Not established

Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: IARC-3, TLV-A3 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Diethanolamine

NIOSH: Pocket Guide to Chemical Hazards - Diethanolamine

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Diethanolamine. See annual publication for most recent information.
  • EPA Air Toxics Website: Diethanolamine. U.S. Environmental Protection Agency Technology Transfer Network.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Diethanolamine.
  • Mathews, J.M., Garner, C.E. and Matthews, H.B.: Metabolism, bioaccumulation, and incorporation of diethanolamine into phospholipids. Chem. Res. Toxicol. 8(5): 625-633, 1995.
  • Mirer, F.: Updated epidemiology of workers exposed to metalworking fluids provides sufficient evidence for carcinogenicity. Appl. Occup. Environ. Hyg. 18(11):902-912, 2003.
  • National Toxicology Program: NTP Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies). Natl. Toxicol. Program Tech. Rep. Ser. 478: 1-212, 1999.
  • Piipari, R., et al.: Diethanolamine-induced occupational asthma, a case report. Clin. Exp. Allergy 28(3): 358-362, 1998.
  • Pohanish, R.P. (editor): Diethanolamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 860-862.

Last Updated Date : 12/28/2020