2-ETHOXYETHYL ACETATE (CELLOSOLVE ACETATE)†

Chemical Identification
Chemical Identification
CAS # 111-15-9
Formula

C₆H₁₂O₃

Synonyms

2-ethoxyethyl acetate; cellosolve acetate; EGEEA; ethylene glycol monoethyl ether acetate; glycol monoethyl ether acetate

Physical Properties
Physical Properties
Physical description Colorless liquid with a mild odor.
Boiling point 313°F Molecular weight 132.2
Freezing point/melting point -79°F Vapor pressure 2 mmHg
Flash point 135°F Vapor density 4.72
Specific gravity 0.98 Ionization potential
Lower explosive limit (LEL) 1.7% Upper explosive limit (UEL) 6.7%
NFPA health rating 2 NFPA fire rating 2
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1037
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
Sampling volume (TWA)*

10 L

Sampling flow rate (TWA)*

0.1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference OSHA 53 (fully validated)
Notes

Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory.

Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media

Wipe with charcoal pad, seal in glass vial for shipment. [3M 3500]

Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

100 ppm (540 mg/m³)

REL-TWA

0.5 ppm (2.7 mg/m³)

TLV-TWA
 

5 ppm [1981]

PEL-TWA
 

5 ppm (27 mg/m³)

PEL-STEL REL-STEL
 

 

TLV-STEL
 

 

PEL-STEL
 

 

PEL-C REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation

Y

Skin notation
 

Y

Skin notation
 

Y

Skin notation
 

Y

Notes:

See 29 CFR 1910.1000 Table Z-1.

Notes:
 

 

Notes:
 

BEI®

Notes:
 

 

Health factors:  See NIH-NLM PubChem. IDLH
 

500 ppm

Carcinogenic classifications: Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Ethylene glycol monoethyl ether acetate

NIOSH: Pocket Guide to Chemical Hazards - 2-Ethoxyethyl acetate

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 2-Ethoxyethyl acetate. See annual publication for most recent information.
  • MMWR: Criteria for a recommended standard: occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates. Morbidity and mortality weekly report 41(21): 386, 1992.
  • Dugard, P.H., Walker, M., Mawdsley, S.J. and Scott, R.C.: Absorption of some glycol ethers through human skin in vitro. Environ. Health Perspect. 57: 193-197, 1984.
  • Johnson, W., Jr., Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Int. J. Toxicol. 21(Suppl. 1): 9-62, 2002.
  • Nelson, B.K., et al.: Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats. Environ. Health Perspect. 57: 261-271, 1984.
  • Pohanish, R.P. (editor): 2-Ethoxyethyl Acetate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1037-1039.
  • Söhnlein, B., Letzel, S., Weltle, D., Rüdiger, H.W. and Angerer, J.: Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers. Int. Arch. Occup. Environ. Health 64(7): 479-484, 1993.
  • Stott, W.T. and McKenna, M.J.: Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro. Fundam. Appl. Toxicol. 5(2): 399-404, 1985.
  • Zissu, D.: Experimental study of cutaneous tolerance to glycol ethers. Contact Dermatitis 32(2): 74-77, 1995.

Last Updated Date : 12/15/2020