CYCLOHEXANE†

Chemical Identification
Chemical Identification
CAS # 110-82-7
Formula

C₆H₁₂

Synonyms

benzene hexahydride; hexahydrobenzene; hexamethylene; hexanaphthene

Physical Properties
Physical Properties
Physical description Colorless liquid with a sweet, chloroform-like odor.
Boiling point 177°F Molecular weight 84.2
Freezing point/melting point 44°F Vapor pressure 78 mmHg
Flash point 0°F Vapor density 2.9
Specific gravity 0.78 Ionization potential 9.88 eV
Lower explosive limit (LEL) 1.3% Upper explosive limit (UEL) 8%
NFPA health rating 1 NFPA fire rating 3
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0810 0810
Sampling group OVSG-1
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01] SKC 575-002 Passive Sampler [SKC 575-002]
Sampling time*

190 min

240 min 

Sampling volume (TWA)*

9.5 L

Sampling flow rate (TWA)*

0.05 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID GC-FID
Method reference OSHA 5000 (fully validated) OSHA 1022 (fully validated)
Notes

To obtain sampling and analytical error similar to that available with active sampling, knowledge of the atmospheric pressure and temperature are required, and these should be obtained using NIST-traceable devices. If that is not possible, temperature is assumed to be 22.2 °C, and the atmospheric pressure is estimated based on the elevation of the sampling location.

When estimates are used in place of traceable measurements the sampling and analytical error associated with passive sampling is substantially increased, and this makes it more difficult to demonstrate overexposures after considering the 95% lower confidence limit.

Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

300 ppm (1050 mg/m³)

REL-TWA

300 ppm (1050 mg/m³)

TLV-TWA

100 ppm [1964]

PEL-TWA

300 ppm (1050 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

N

Skin notation

N

Skin notation

N

Skin notation

N

Notes:

See 29 CFR 1910.1000 Table Z-1.

Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH

1300 ppm

Carcinogenic classifications: EPA-I Notes:

10% of LEL

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Cyclohexane

NIOSH: Pocket Guide to Chemical Hazards - Cyclohexane

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Cyclohexane. See annual publication for most recent information.
  • EPA Cyclohexane (CASRN 110-82-7), 2003
  • EPA Toxicological Review of Cyclohexane in Support of IRIS listing, 2003
  • Kreckmann, KH; Baldwin, JK; Roberts, LG; et al. (2000) Inhalation developmental toxicity and reproduction studies with cyclohexane. Drug Chem Toxicol 23(4):555-73.
  • Mráz, J. Gálová, E., Nohová, H. and Vítková, D.: 1,2- and 1,4-Cyclohexanediol - major urinary metabolites and biomarkers of exposure to cyclohexane, cyclohexanone, and cyclohexanol in humans. Int. Arch. Occup. Environ. Health 71(8): 560-565, 1998.
  • NIOSH: Occupational Health Guideline - Cyclohexane. 1978.
  • Yasugi, T. et al.: Exposure monitoring and health effect studies of workers occupationally exposed to cyclohexane vapor. Int. Arch. Occup. Environ. Health 65(5): 343-350, 1994.

Last Updated Date : 04/13/2021