2-ETHOXYETHANOL (CELLOSOLVE; GLYCOL MONOETHYL ETHER)†

Chemical Identification
Chemical Identification
CAS # 110-80-5
Formula

C₄H₁₀O₂

Synonyms

Cellosolve; EGEE; ethylene glycol monoethyl ether

Physical Properties
Physical Properties
Physical description Colorless liquid with a sweet, pleasant, ether-like odor.
Boiling point 275°F Molecular weight 90.14.
Freezing point/melting point -94°F Vapor pressure 4 mmHg
Flash point 105°F Vapor density 3.1
Specific gravity 0.93 Ionization potential
Lower explosive limit (LEL) 1.8% Upper explosive limit (UEL) 14%
NFPA health rating 1 NFPA fire rating 2
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1033
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
Sampling volume (TWA)*

10 L

Sampling flow rate (TWA)*

0.1 L/min

Sampling volume (STEL/Peak/C)*
 

 

Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference OSHA 53 (fully validated)
Notes
Special requirements
 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

200 ppm (740 mg/m³)

REL-TWA
 

0.5 ppm (18 mg/m³)

TLV-TWA
 

5 ppm [1981]

PEL-TWA
 

5 ppm (18 mg/m³)

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

 

PEL-STEL
 

 

PEL-C
 

 

REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation
 

Y

Skin notation
 

Y

Skin notation
 

Y

Skin notation
 

Y

Notes:
 

See 29 CFR 1910.1000 Table Z-1.

Notes:
 

 

Notes:
 

BEI®

Notes:
 

 

Health factors:  See NIH-NLM PubChem. IDLH
 

500 ppm

Carcinogenic classifications: Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Ethylene glycol monoethyl ether

NIOSH: Pocket Guide to Chemical Hazards - 2-Ethoxyethanol

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 2-Ethoxyethanol. See annual publication for most recent information.
  • U.S. EPA Integrated Risk Information System: 2-Ethoxyethanol (CASRN 110-80-5).
  • MMWR: Criteria for a recommended standard: occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates. Morbidity and mortality weekly report 41(21): 386, 1992.
  • Groeseneken, D., Veulemans, H. and Masschelein, R: Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycol monoethyl ether. Br. J. Ind. Med. 43(9): 615-619, 1986.
  • Johnson, W., Jr., Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Int. J. Toxicol. 21(Suppl. 1): 9-62, 2002.
  • Kežić, S., Mahieu, K., Monster, A.C. and de Wolff, F.A.: Dermal absorption of vaporous and liquid 2-methoxyethanol and 2-ethoxyethanol in volunteers. Occup. Environ. Med. 54(1): 38-43, 1997.
  • Pohanish, R.P. (editor): 2-Ethoxyethanol. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1035-1037.
  • Zissu, D.: Experimental study of cutaneous tolerance to glycol ethers. Contact Dermatitis 32(2): 74-77, 1995.

Last Updated Date : 09/21/2022