METHYL ISOAMYL KETONE†

Chemical Identification
Chemical Identification
CAS # 110-12-3
Formula

C₇H₁₄O

Synonyms
 

isoamyl methyl ketone; isopentyl methyl ketone; 2-methyl-5-hexanone; 5-methyl-2-hexanone; MIAK; 5-methylhexan-2-one

Physical Properties
Physical Properties
Physical description Colorless, clear liquid with a pleasant, fruity odor.
Boiling point 291°F Molecular weight 114.2
Freezing point/melting point -101°F Vapor pressure 5 mmHg
Flash point 97°F Vapor density
Specific gravity 0.81 Ionization potential 9.284 eV
Lower explosive limit (LEL) 1% at 200°F Upper explosive limit (UEL) 8.2% at 200°F
NFPA health rating 1 NFPA fire rating 3
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1776
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
 

50 min

Sampling volume (TWA)*
 

10 L

Sampling flow rate (TWA)*
 

0.2 L/min

Sampling volume (STEL/Peak/C)*
 

 

Sampling flow rate (STEL/Peak/C)*
 

 

Analytical method instruments GC-FID
Method reference OSHA PV2042 (partially validated)
Notes
 

 

Special requirements
 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

100 ppm (475 mg/m³)

REL-TWA
 

50 ppm (240 mg/m³)

TLV-TWA
 

20 ppm [2012]

PEL-TWA
 

50 ppm (234 mg/m³)

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

50 ppm [2012]

PEL-STEL
 

 

PEL-C
 

 

REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation
 

N

Skin notation
 

N

Skin notation
 

N

Skin notation
 

N

Notes:
 

See 29 CFR 1910.1000 Table Z-1.

Notes:
 

 

Notes:
 

 

Notes:
 

 

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Not listed Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - 5-Methylhexan-2-one

NIOSH: Pocket Guide to Chemical Hazards - Methyl isoamyl ketone

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Methyl isoamyl ketone. See annual publication for most recent information.
  • De Ceaurriz, J., Micillino, J.C., Marignac, B., Bonnet, P., Muller, J. and Guenier, J.P.: Quantitative evaluation of sensory irritating and neurobehavioral properties of aliphatic ketones in mice. Food Chem. Toxicol. 22(7): 545-549, 1984.
  • Katz, G.V., Renner, E.R., Jr. and Terhaar, C.J.: Subchronic inhalation toxicity of methyl isoamyl ketone in rats. Fundam. Appl. Toxicol. 6(3): 498-505, 1986.
  • Pohanish, R.P. (editor): Methyl Isoamyl Ketone. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1578-1580.

Last Updated Date : 01/05/2021