N-NITROSODIETHANOLAMINE

Chemical Identification
Chemical Identification
CAS # 1116-54-7
Formula

C₄H₁₀N₂O₃

Synonyms

NDELA; DELNA; 2,2'-iminodi-N-nitrosoethanol; bis(β-hydroxyethyl)nitrosamine; nitrosoiminodiethanol; 2,2'-(nitrosoimino) bis[ethanol]; N-nitrosobis(2-hydroxyethyl)amine; NCI-C55583; diethylamine, 2,2'-dihydroxy-N-nitroso; diethanolnitrosamine

Physical Properties
Physical Properties
Physical description Yellow to dark brown very viscous liquid with no distinct odor.
Boiling point 237°F at 1.5 mmHg Molecular weight 134.16
Freezing point/melting point Vapor pressure
Flash point Vapor density
Specific gravity 1.28 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0907
Sampling group
Sampler/Sampling media GFF Gelman Type A (37 mm) in 3-piece cassette no backup pad [SKC 225-706]
Sampling time*

240 min

Sampling volume (TWA)*

480 L

Sampling flow rate (TWA)*

2 L/min

Sampling volume (STEL/Peak/C)*
 

 

Sampling flow rate (STEL/Peak/C)*
 

 

Analytical method instruments HPLC
Method reference OSHA 31 (fully validated)
Notes
 

Sample open-faced!! Store samples in freezer. 

Special requirements
 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

Limit the amount of bulk submitted to 1 g or 1 mL.

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

REL-TWA
 

 

TLV-TWA
 

 

PEL-TWA
 

 

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

 

PEL-STEL
 

 

PEL-C
 

 

REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation
 

NA

Skin notation
 

NA

Skin notation
 

NA

Skin notation
 

NA

Notes:
 

Not established

Notes:
 

Not established

Notes:
 

Not established

Notes:
 

Not established

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: NTP, IARC-2B, EPA-B2 Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosodiethanolamine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosodiethanolamine

Literature References

 
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KL9550000.
  • U.S. EPA Integrated Risk Information System: N-Nitrosodiethanolamine (CASRN 1116-54-7).
  • Ducos, P. and Gaudin, R.: N-nitrosodiethanolamine urinary excretion in workers exposed to aqueous metalworking fluids. Int. Arch. Occup. Environ. Health 76(8): 591-597, 2003.
  • Fuchs, J., Burg, J., Hengstler, J.G., Bolm-Audorff, U. and Oesch, F.: DNA damage in mononuclear blood cells of metal workers exposed to N-nitrosodiethanolamine in synthetic cutting fluids. Mutat. Res. 342(1-2): 95-102, 1995.
  • Loeppky, R.N., Goelzer, P. and Chen, Y.: DNA adducts from N-nitrosodiethanolamine and related β-oxidized nitrosamines in vivo: (32)P-postlabeling methods for glyoxal- and O(6)-hydroxyethyldeoxyguanosine adducts. Chem. Res. Toxicol. 15(4): 470-482, 2002.
  • No Author: N-Nitrosodiethanolamine . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.

Last Updated Date : 01/05/2021