N-NITROSOPYRROLIDINE

Chemical Identification
CAS #	930-55-2
Formula	C₄H₈N₂O
Synonyms	NO-Pyr; NPYR; 1-nitroso-pyrrolidine; N-N-Pyr

Physical Properties
Physical description	Yellow liquid.
Boiling point	417°F	Molecular weight	100.14
Freezing point/melting point		Vapor pressure
Flash point	181°F	Vapor density
Specific gravity	1.085	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1950
Sampling group
Sampler/Sampling media	ThermoSorb/N air sampler [No longer available]
Sampling time^*	75 min
Sampling volume (TWA)^*	75 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	GC-TEA
Method reference	OSHA 27 (fully validated)
Notes	This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-5100.
Special requirements	Store samples in freezer.

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
Bulk Method

On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

**Exposure Limits**
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	NA
Notes: Not established		Notes: Not established		Notes: Not established		Notes: Not established
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: NTP, IARC-2B, EPA-B2		Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosopyrrolidine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosopyrrolidine

Literature References

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UY1575000.
U.S. EPA Integrated Risk Information System: N-Nitrosopyrrolidine (CASRN 930-55-2).
Hunt, E.J. and Shank, R.C.: Formation and persistence of a DNA adduct in rodents treated with N-nitrosopyrrolidine. Carcinogenesis 12(4): 571-575, 1991.
McCoy, G.D., DeMarco, G.J., Haxhiu, L., Roggero, E., Sudilovsky, E.C. and Sudilovsky, O.: Effect of acute administration of N-nitrosopyrrolidine to male Syrian golden hamsters. Cancer Lett. 79(2): 161-165, 1994.
No Author: N-Nitrosopyrrolidine . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
Pohanish, R.P. (editor): N-Nitrosopyrrolidine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1743-1744.
Siddiqi, M.A., Tricker, A.R., Kumar, R., Fazili, Z. and Preussmann, R.: Dietary sources of N-nitrosamines in a high-risk area for oesophageal cancer-Kashmir, India. IARC Sci. Publ. (105): 210-213, 1991.
Wong, M. and Hecht, S.S.: A cyclic N7,C8 guanine adduct of N-nitrosopyrrolidine (NPYR): formation in nucleic acids and excretion in the urine of NPYR-treated rats. Chem. Res. Toxicol. 10(7): 772-778, 1997.
Wong, H.L., Murphy, S.E. and Hecht, S.S.: Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chem. Res. Toxicol. 18(1): 61-69, 2005.

Last Updated Date : 01/22/2024

N-NITROSOPYRROLIDINE

Chemical Identification

Physical Properties

Monitoring Methods Used by OSHA

Bulk/Wipe Method

On-Site Screening Techniques

Exposure Limits

Additional Resources and Literature References