N-NITROSOPIPERIDINE

Chemical Identification
Chemical Identification
CAS # 100-75-4
Formula

C₅H₁₀N₂O

Synonyms
 

NPIP; NO-Pip; 1-nitrosopiperidine

Physical Properties
Physical Properties
Physical description Light yellow oil or liquid.
Boiling point 423°F at 721 mmHg Molecular weight 114.17
Freezing point/melting point Vapor pressure
Flash point Vapor density
Specific gravity 1.0631 at 65.3°F Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1949
Sampling group
Sampler/Sampling media ThermoSorb/N air sampler [No longer available]
Sampling time*
 

75 min

Sampling volume (TWA)*
 

75 L

Sampling flow rate (TWA)*
 

1 L/min

Sampling volume (STEL/Peak/C)*
 

 

Sampling flow rate (STEL/Peak/C)*
 

 

Analytical method instruments GC-TEA
Method reference OSHA 27 (fully validated)
Notes
 

This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-4900.

Special requirements
 

Store samples in freezer.

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

REL-TWA
 

 

TLV-TWA
 

 

PEL-TWA
 

 

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

 

PEL-STEL
 

 

PEL-C
 

 

REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation
 

NA

Skin notation
 

NA

Skin notation
 

NA

Skin notation
 

NA

Notes:
 

Not established

Notes:
 

Not established

Notes:
 

Not established

Notes:
 

Not established

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: NTP, IARC-2B Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-Nitrosopiperidine

NIOSH: Pocket Guide to Chemical Hazards - N-Nitrosopiperidine

Literature References

 
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TN2100000.
  • No Author: Nitrosamines, 15 Listings . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • Levallois, P., et al.: Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption. Food Chem. Toxicol. 38(11): 1013-1019, (2000).
  • Pohanish, R.P. (editor): N-Nitrosopiperidine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, (2002), pp. 1741-1742.
  • Siddiqi, M.A., Tricker, A.R., Kumar, R., Fazili, Z. and Preussmann, R.: Dietary sources of N-nitrosamines in a high-risk area for oesophageal cancer-Kashmir, India. IARC Sci. Publ. (105): 210-213, (1991).
  • Wong, H.L., Murphy, S.E. and Hecht, S.S.: Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine. Chem. Res. Toxicol. 18(1): 61-69, (2005).

Last Updated Date : 01/07/2021