N-NITROSODIPROPYLAMINE

Chemical Identification
Chemical Identification
CAS # 621-64-7
Formula

C₆H₁₄N₂O

Synonyms

NDPA; di-n-propylnitrosamine; N-nitrosodi-n-propylamine; DPNA; DPN; N-nitroso-N-propyl-1-propanamine; propylamine, N-nitroso-N-di; dipropylnitrosamine; N-propyl-N-nitrosopropylamine

Physical Properties
Physical Properties
Physical description Clear to pale yellow liquid.
Boiling point 403°F Molecular weight 130.19
Freezing point/melting point Vapor pressure
Flash point Vapor density
Specific gravity 0.9163 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1948
Sampling group
Sampler/Sampling media ThermoSorb/N air sampler [No longer available]
Sampling time*

75 min

Sampling volume (TWA)*

75 L

Sampling flow rate (TWA)*

1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-TEA
Method reference OSHA 27 (fully validated)
Notes
 

This media is no longer available. OSHA staff please contact the SLTC prior to sampling at (801) 233-4900.

Special requirements
 

Store samples in freezer.

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

REL-TWA
 

 

TLV-TWA
 

 

PEL-TWA
 

 

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

 

PEL-STEL
 

 

PEL-C
 

 

REL-C
 

 

TLV-C
 

 

PEL-C
 

 

Skin notation
 

NA

Skin notation
 

NA

Skin notation
 

NA

Skin notation
 

NA

Notes:
 

Not established

Notes:
 

Not established

Notes:
 

Not established

Notes:
 

Not established

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: NTP, IARC-2B, EPA-B2 Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - N-nitrosodi-n-propylamine

NIOSH: Pocket Guide to Chemical Hazards - N-nitrosodi-n-propylamine

Literature References

 
  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: JL9700000.
  • U.S. EPA Integrated Risk Information System: N-Nitrosodi-N-propylamine (CASRN 621-64-7).
  • Agency for Toxic Substances and Disease Registry (ATSDR): Toxicological Profile for N-nitrosodi-n-propylamine. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, 1989.
  • California Department of Health Services: California drinking water; activities related to NDMA and other nitrosamines, 2005.
  • No Author: N-Nitrosodi-n-Propylamine . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • Pohanish, R.P. (editor): N-Nitrosodipropylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1736-1738.
  • Teiber, J.F. and Hollenberg, P.F.: Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine. Carcinogenesis 21(8): 1559-1566, 2000.
  • Teiber, J.F., Macé, K. and Hollenberg, P.F.: Metabolism of the β-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-β-hydroxypropylpropylamine and N-nitroso-β-oxypropylpropylamine. Carcinogenesis 22(3): 499-506, 2001.

Last Updated Date : 01/05/2021