1. OSHA Occupational Chemical Database
  2. ESTRIOL
Label abbreviations descriptions

ESTRIOL

Chemical Identification
Chemical Identification
CAS # 50-27-1
Formula
 

C₁₈H₂₄O₃
Synonyms
 

Destriol; 1,3,5-estratriene-3-β,16-α, 17-β-triol; trihydroxyestrin
Physical Properties
Physical Properties
Physical description Odorless white crystals.
Boiling point Molecular weight 288.39
Freezing point/melting point 282°C Vapor pressure
Flash point Vapor density
Specific gravity Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) E321
Sampling group
Sampler/Sampling media GFF Gelman Type A (37 mm) in 3-piece cassette no backup pad [SKC 225-706]
Sampling time*
 

240 min
Sampling volume (TWA)*
 

240 L
Sampling flow rate (TWA)*
 

1 L/min
Sampling volume (STEL/Peak/C)*
 

 
Sampling flow rate (STEL/Peak/C)*
 

 
Analytical method instruments HPLC
Method reference OSHA PV2001 (partially validated)
Notes
 

 
Special requirements
 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 
Bulk Method
Bulk Method
 

 
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

 REL-TWA
 

 

 TLV-TWA
 

 

 PEL-TWA
 

 
PEL-STEL
 

 

 REL-STEL
 

 

 TLV-STEL
 

 

 PEL-STEL
 

 
PEL-C
 

 

 REL-C
 

 

 TLV-C
 

 

 PEL-C
 

 
Skin notation
 

NA

 Skin notation
 

NA

 Skin notation
 

NA

 Skin notation
 

NA
Notes:
 

Not established

 Notes:
 

Not established

 Notes:
 

Not established

 Notes:
 

Not established
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: NTP, IARC-1 Notes:
 

 
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

 
  • No Author: Estrogens, Steroidal . Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
  • No Author: Synapause-E3® 2 mg (tablets). South African Electronic Package Inserts.
  • Kuiper, G.G.J.M., et al.: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138(3): 863-870, 1997.
  • Longcope, C.: Estriol production and metabolism in normal women. J. Steroid Biochem. 20(4B): 959-962, 1984.
  • Loose-Mitchell, D.S. and Stancel, G.M.: Estrogens and Progestins (Chapter 58). In, Goodman & Gilman's The Pharmacological Basis of Therapeutics, 10th Ed. J.G. Hardman, L.E. Limbird and A.G. Gilman, eds. New York: McGraw-Hill, 2001, pp. 1597-1634.
  • Weiderpass, E., et al.: Low-potency oestrogen and risk of endometrial cancer: a case-control study. Lancet 353(9167): 1824-1828, 1999.

Last Updated Date : 12/28/2020