1-METHOXY-2-PROPYL ACETATE | Occupational Safety and Health Administration

1-METHOXY-2-PROPYL ACETATE

Chemical Identification
Chemical Identification
CAS #	108-65-6
Formula	C₆H₁₂O₃
Synonyms	1-methoxy-2-acetoxypropane; 2-methoxy-1-methylethyl ester acetic acid; 1-methoxy-2-propanol acetate; 1-methoxy-2-propyl acetate; PGMEA; 1,2-propanediol monomethyl ether acetate; propylene glycol methyl ether acetate; propylene glycol monomethyl ether acetate

Physical Properties
Physical Properties
Physical description	Colorless, flammable liquid with sweet ether-like odor.
Boiling point	302°F	Molecular weight	132.16
Freezing point/melting point		Vapor pressure
Flash point		Vapor density
Specific gravity	0.969	Ionization potential
Lower explosive limit (LEL)	1.3% at 173°F	Upper explosive limit (UEL)	13.1% at 283°F
NFPA health rating	1	NFPA fire rating	2
NFPA reactivity rating	0	NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	P218
Sampling group
Sampler/Sampling media	CSC tube (100/50 mg) [SKC 226-01]
Sampling time^*	100 min
Sampling volume (TWA)^*	10 L
Sampling flow rate (TWA)^*	0.1 L/min
Sampling volume (STEL/Peak/C)^*	3 L
Sampling flow rate (STEL/Peak/C)^*	0.2 L/min
Analytical method instruments	GC-FID
Method reference	OSHA 99 (fully validated)
Notes	Keep samples refrigerated when not in transit. Ship samples overnight with cold-packs as soon as possible.
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media

Bulk Method
Bulk Method

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

Exposure Limits
Exposure Limits
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA		TLV-TWA		PEL-TWA	100 ppm (541 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL	150 ppm (811 mg/m³)
PEL-C		REL-C		TLV-C		PEL-C
Skin notation	NA	Skin notation	NA	Skin notation	NA	Skin notation	Y
Notes: Not established		Notes: Not established		Notes: Not established		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications:		Notes:

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3: Not listed

Additional Resources and Literature References
Additional Resources and Literature References
NOAA: CAMEO Chemicals - Propylene glycol methyl ether acetate NIOSH: Pocket Guide to Chemical Hazards - Propylene glycol methyl ether acetate Literature References NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AI8925000 Domoradzki, J.Y., Brzak, K.A. and Thornton, C.M.: Hydrolysis kinetics of Propylene glycol monomethyl ether acetate in rats in vivo and in rat and human tissues in vitro. Toxicol. Sci. 75(1): 31-39, 2003. Miller, R.R., Hermann, E.A., Young, J.T., Calhoun, L.L. and Kastl, P.E.: Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition, and short-term vapor inhalation toxicity studies. Toxicol. Appl. Pharmacol. 75(3): 521-530, 1984.

Last Updated Date : 09/21/2022