1-METHOXY-2-PROPYL ACETATE

Chemical Identification
Chemical Identification
CAS # 108-65-6
Formula

C₆H₁₂O₃

Synonyms

1-methoxy-2-acetoxypropane; 2-methoxy-1-methylethyl ester acetic acid; 1-methoxy-2-propanol acetate; 1-methoxy-2-propyl acetate; PGMEA; 1,2-propanediol monomethyl ether acetate; propylene glycol methyl ether acetate; propylene glycol monomethyl ether acetate

Physical Properties
Physical Properties
Physical description Colorless, flammable liquid with sweet ether-like odor.
Boiling point 302°F Molecular weight 132.16
Freezing point/melting point Vapor pressure
Flash point Vapor density
Specific gravity 0.969 Ionization potential
Lower explosive limit (LEL) 1.3% at 173°F Upper explosive limit (UEL) 13.1% at 283°F
NFPA health rating 1 NFPA fire rating 2
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) P218
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*

100 min

Sampling volume (TWA)*

10 L

Sampling flow rate (TWA)*

0.1 L/min

Sampling volume (STEL/Peak/C)*

3 L

Sampling flow rate (STEL/Peak/C)*

0.2 L/min

Analytical method instruments GC-FID
Method reference OSHA 99 (fully validated)
Notes

Samples should be refrigerated upon receipt by the laboratory.

Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA TLV-TWA PEL-TWA

100 ppm (541 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL

150 ppm (811 mg/m³)

PEL-C REL-C TLV-C PEL-C
Skin notation

NA

Skin notation

NA

Skin notation

NA

Skin notation

Y

Notes:

Not established

Notes:

Not established

Notes:

Not established

Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Not listed

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Propylene glycol methyl ether acetate

NIOSH: Pocket Guide to Chemical Hazards - Not listed

Literature References

  • NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AI8925000
  • Domoradzki, J.Y., Brzak, K.A. and Thornton, C.M.: Hydrolysis kinetics of Propylene glycol monomethyl ether acetate in rats in vivo and in rat and human tissues in vitro. Toxicol. Sci. 75(1): 31-39, 2003.
  • Miller, R.R., Hermann, E.A., Young, J.T., Calhoun, L.L. and Kastl, P.E.: Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition, and short-term vapor inhalation toxicity studies. Toxicol. Appl. Pharmacol. 75(3): 521-530, 1984.

Last Updated Date : 12/15/2020