1. OSHA Occupational Chemical Database
  2. ISOPROPYL ACETATE
Label abbreviations descriptions

ISOPROPYL ACETATE†

Chemical Identification
Chemical Identification
CAS # 108-21-4
Formula

C₅H₁₀O₂
Synonyms

isopropyl ester of acetic acid; 1-methylethyl ester of acetic acid; 2-propyl acetate
Physical Properties
Physical Properties
Physical description Colorless liquid with a fruity odor.
Boiling point 194°F Molecular weight 102.15
Freezing point/melting point -100.1°F Vapor pressure 1 mmHg at -36.9°F, 100 mmHg at 96.3°F, 760 mmHg at 192.2°F
Flash point 36°F Vapor density 3.5
Specific gravity 0.874 Ionization potential 9.95 eV
Lower explosive limit (LEL) 1.8% at 100°F Upper explosive limit (UEL) 8%
NFPA health rating 2 NFPA fire rating 3
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1540
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
Sampling volume (TWA)*

0.1-9 L
Sampling flow rate (TWA)*

0.02-0.2 L/min
Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference NIOSH 1454 (partially validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

250 ppm (950 mg/m³)

 REL-TWA TLV-TWA

100 ppm [2017]

 PEL-TWA

250 ppm (950 mg/m³)
PEL-STEL REL-STEL TLV-STEL

150 ppm [2017]

 PEL-STEL

310 ppm (1185 mg/m³)
PEL-C REL-C TLV-C PEL-C
Skin notation

N

 Skin notation

N

 Skin notation

N

 Skin notation

N
Notes:

See 29 CFR 1910.1000 Table Z-1.

 Notes:

See Appendix D - Substances with No Established RELs.

 Notes:

as propyl acetate isomers [108-21-4; 109-60-4]

 Notes:
Health factors:  See NIH-NLM PubChem. IDLH

1800 ppm
Carcinogenic classifications: Not listed Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Isopropyl acetate

NIOSH: Pocket Guide to Chemical Hazards - Isopropyl acetate

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Propyl acetate isomers. See annual publication for most recent information.
  • Pohanish, R.P. (editor): Isopropyl Acetate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1350-1352.
  • Zakko, S.F., Scirica, J.C., Guttermuth, M.C., Dodge, J. and Hajjar, J.-J.: Ethyl propionate is more effective and less cytotoxic than methyl tert-butyl ether for topical gallstone dissolution. Gastroenterology 113(1): 232-237, 1997.

Last Updated Date : 12/31/2020