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HEXAMETHYLENE DIISOCYANATE
| CAS # | 822-06-0 |
|---|---|
| Formula |
C₈H₁₂N₂O₂ |
| Synonyms |
1,6-diisocyanatohexane, HDI, hexamethylene-1,6-diisocyanate, 1,6-hexamethylene diisocyanate |
| Physical description | Clear, colorless to slightly yellow liquid with a sharp, pungent odor. | ||
|---|---|---|---|
| Boiling point | 415°F | Molecular weight | 168.2 |
| Freezing point/melting point | -89°F | Vapor pressure | 0.5 mmHg |
| Flash point | 284°F | Vapor density | |
| Specific gravity | 1.0528 | Ionization potential | |
| Lower explosive limit (LEL) | Upper explosive limit (UEL) | ||
| NFPA health rating | NFPA fire rating | ||
| NFPA reactivity rating | NFPA special instruction | ||
| Vapor hazard ratio (VHR) | |||
| Historical exceedance percentage | |||
| Target organs | |||
| Analyte code (IMIS no.) | 1377 |
|---|---|
| Sampling group | |
| Sampler/Sampling media | Isocyanate Sampling Filter Kit - GFF (37 mm, open-faced) coated with 1 mg 1-(2-pyridyl)piperazine [SLTC103] |
| Sampling time* | 15 min |
| Sampling volume (TWA)* |
15 L |
| Sampling flow rate (TWA)* |
1 L/min |
| Sampling volume (STEL/Peak/C)* |
|
| Sampling flow rate (STEL/Peak/C)* |
|
| Analytical method instruments | UHPLC |
| Method reference | OSHA 5002 (fully validated) |
| Notes |
Results may not reflect accurate exposures to the polymeric forms of isocyanates. Refrigerate coated filters until used. Sample open-faced!! |
| Special requirements |
|
* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.
| Wipe Sampler/Sampling media |
|
|---|---|
| Bulk Method |
|
| Device | Hazard Assessment Test Kit for Aliphatic Isocyanates |
|---|---|
| Model/Type | 769-1003 |
|
Sampling information (see manufacturer instructions) |
Isocyanate Surface and Dermal Sampling, Hazard Assessment Test Kit for Aliphatic Isocyanates |
|
OSHA PEL
8-hour TWA (ST) STEL (C) Ceiling Peak |
NIOSH REL
Up to 10-hour TWA (ST) STEL (C) Ceiling |
ACGIH TLV©
8-hour TWA (ST) STEL (C) Ceiling |
|||||
|---|---|---|---|---|---|---|---|
| PEL-TWA |
|
REL-TWA |
0.005 ppm (0.035 mg/m³) |
TLV-TWA |
0.005 ppm [1985] |
PEL-TWA |
0.005 ppm (0.034 mg/m³) |
| PEL-STEL |
|
REL-STEL |
|
TLV-STEL |
|
PEL-STEL |
|
| PEL-C |
|
REL-C |
0.020 ppm (0.140 mg/m³) [10 minutes] |
TLV-C |
|
PEL-C |
|
| Skin notation |
NA |
Skin notation |
N |
Skin notation |
N |
Skin notation |
N |
|
Notes:
Not established |
Notes:
|
Notes:
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Notes:
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| Health factors: See NIH-NLM PubChem. | IDLH | ||||||
| Carcinogenic classifications: Not listed |
Notes:
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|
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
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Additional Resources and Literature References
|
NOAA: CAMEO Chemicals - Hexamethylene diisocyanate NIOSH: Pocket Guide to Chemical Hazards - Hexamethylene diisocyanate Literature References
|
Last Updated Date : 04/02/2025