Label abbreviations descriptions

HEXAMETHYLENE DIISOCYANATE

Chemical Identification
CAS # 822-06-0
Formula

C₈H₁₂N₂O₂
Synonyms

1,6-diisocyanatohexane, HDI, hexamethylene-1,6-diisocyanate, 1,6-hexamethylene diisocyanate

Physical Properties
Physical description Clear, colorless to slightly yellow liquid with a sharp, pungent odor.
Boiling point 415°F Molecular weight 168.2
Freezing point/melting point -89°F Vapor pressure 0.5 mmHg
Flash point 284°F Vapor density
Specific gravity 1.0528 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1377
Sampling group
Sampler/Sampling media Isocyanate Sampling Filter Kit - GFF (37 mm, open-faced) coated with 1 mg 1-(2-pyridyl)piperazine [SLTC103]
Sampling time*

15 min
Sampling volume (TWA)*
 

15 L
Sampling flow rate (TWA)*
 

1 L/min
Sampling volume (STEL/Peak/C)*
 

 
Sampling flow rate (STEL/Peak/C)*
 

 
Analytical method instruments UHPLC
Method reference OSHA 5002 (fully validated)
Notes
 

Results may not reflect accurate exposures to the polymeric forms of isocyanates. Refrigerate coated filters until used. Sample open-faced!!
Special requirements
 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Bulk/Wipe Method
Wipe Sampler/Sampling media
 

 
Bulk Method
 

 

On-Site Screening Techniques
Device Hazard Assessment Test Kit for Aliphatic Isocyanates
Model/Type 769-1003
Sampling information
(see manufacturer instructions) 		Isocyanate Surface and Dermal Sampling, Hazard Assessment Test Kit for Aliphatic Isocyanates

Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

 REL-TWA
 

0.005 ppm (0.035 mg/m³)

 TLV-TWA
 

0.005 ppm [1985]

 PEL-TWA
 

0.005 ppm (0.034 mg/m³)
PEL-STEL
 

 

 REL-STEL
 

 

 TLV-STEL
 

 

 PEL-STEL
 

 
PEL-C
 

 

 REL-C
 

0.020 ppm (0.140 mg/m³) [10 minutes]

 TLV-C
 

 

 PEL-C
 

 
Skin notation
 

NA

 Skin notation
 

N

 Skin notation
 

N

 Skin notation
 

N
Notes:
 

Not established

 Notes:
 

 

 Notes:
 

 

 Notes:
 

 
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Not listed Notes:
 

 
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References

Last Updated Date : 04/02/2025