HEXAMETHYLENE DIISOCYANATE | Occupational Safety and Health Administration

HEXAMETHYLENE DIISOCYANATE

Chemical Identification
Chemical Identification
CAS #	822-06-0, 11142-52-2
Formula	C₈H₁₂N₂O₂
Synonyms	1,6-diisocyanatohexane, HDI, hexamethylene-1,6-diisocyanate, 1,6-hexamethylene diisocyanate

Physical Properties
Physical Properties
Physical description	Clear, colorless to slightly yellow liquid with a sharp, pungent odor.
Boiling point	415°F	Molecular weight	168.2
Freezing point/melting point	-89°F	Vapor pressure	0.5 mmHg
Flash point	284°F	Vapor density
Specific gravity	1.0528	Ionization potential
Lower explosive limit (LEL)		Upper explosive limit (UEL)
NFPA health rating		NFPA fire rating
NFPA reactivity rating		NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs

Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.)	1377
Sampling group
Sampler/Sampling media	Isocyanate Sampling Filter Kit - GFF (37 mm, open-faced) coated with 1 mg 1-(2-pyridyl)piperazine [SLTC103]
Sampling time^*	15 min
Sampling volume (TWA)^*	15 L
Sampling flow rate (TWA)^*	1 L/min
Sampling volume (STEL/Peak/C)^*
Sampling flow rate (STEL/Peak/C)^*
Analytical method instruments	UHPLC
Method reference	OSHA 5002 (fully validated)
Notes	Results may not reflect accurate exposures to the polymeric forms of isocyanates. Refrigerate coated filters until used. Sample open-faced!!
Special requirements

^* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media

Bulk Method
Bulk Method

On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information (see manufacturer instructions)

Exposure Limits
Exposure Limits
OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak		NIOSH REL Up to 10-hour TWA (ST) STEL (C) Ceiling		ACGIH TLV© 8-hour TWA (ST) STEL (C) Ceiling		CAL/OSHA PEL 8-hour TWA (ST) STEL (C) Ceiling Peak
PEL-TWA		REL-TWA	0.005 ppm (0.035 mg/m³)	TLV-TWA	0.005 ppm [1985]	PEL-TWA	0.005 ppm (0.034 mg/m³)
PEL-STEL		REL-STEL		TLV-STEL		PEL-STEL
PEL-C		REL-C	0.020 ppm (0.140 mg/m³) [10 minutes]	TLV-C		PEL-C
Skin notation	NA	Skin notation	N	Skin notation	N	Skin notation	N
Notes: Not established		Notes:		Notes:		Notes:
Health factors: See NIH-NLM PubChem.		IDLH
Carcinogenic classifications: Not listed		Notes:

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

Additional Resources and Literature References
Additional Resources and Literature References
NOAA: CAMEO Chemicals - Hexamethylene diisocyanate NIOSH: Pocket Guide to Chemical Hazards - Hexamethylene diisocyanate Literature References ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Hexamethylene diisocyanate. See annual publication for most recent information. EPA: Hazard Summary - Hexamethylene Diisocyanate. NIOSH: Criteria for a Recommended Standard - Occupational Exposure to Diisocyanates. September 1978. NIOSH: Preventing Asthma and Death from Diisocyanate Exposure. DHHS (NIOSH) Publication No. 96-111. 1996. NIOSH: Recommendation for Occupational Safety and Health - Compendium of Policy Documents and Statements . Cincinnati, OH: U.S. Department of Health and Human Services. NIOSH Publication No. 92-100. 1992. Pohanish, R.P. (editor): Hexamethylene Diisocyanate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, pp. 1252-1254, 2002.

Last Updated Date : 04/14/2021