DIMETHYLFORMAMIDE†

Chemical Identification
Chemical Identification
CAS # 68-12-2
Formula

C₃H₇NO

Synonyms

DMF; DMFA; N,N-dimethylformamide; composite constituent; dimethyl formamide

Physical Properties
Physical Properties
Physical description Colorless to pale-yellow liquid with a faint, amine-like odor.
Boiling point 307°F Molecular weight 73.1
Freezing point/melting point -78°F Vapor pressure 3 mmHg
Flash point 136°F Vapor density 2.51
Specific gravity 0.95 Ionization potential 9.12 eV
Lower explosive limit (LEL) 2.2% at 212°F Upper explosive limit (UEL) 15.2% at 212°F
NFPA health rating 2 NFPA fire rating 2
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0930
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*

50 min

Sampling volume (TWA)*

10 L

Sampling flow rate (TWA)*

0.2 L/min

Sampling volume (STEL/Peak/C)*

3 L

Sampling flow rate (STEL/Peak/C)*

0.2 L/min

Analytical method instruments GC-NPD
Method reference OSHA 66 (fully validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media

Wipe with charcoal pad, seal in glass vial for shipment. [3M 3500]

Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA

10 ppm (30 mg/m³)

REL-TWA

10 ppm (30 mg/m³)

TLV-TWA

5 ppm [2017]

PEL-TWA

10 ppm (30 mg/m³)

PEL-STEL REL-STEL TLV-STEL PEL-STEL
PEL-C REL-C TLV-C PEL-C
Skin notation

Y

Skin notation

Y

Skin notation

Y

Skin notation

Y

Notes:

See 29 CFR 1910.1000 Table Z-1.

Notes: Notes:

BEI®

Notes:
Health factors:  See NIH-NLM PubChem. IDLH

500 ppm

Carcinogenic classifications: IARC-3, TLV-A3 Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

2 ppm/100 ppm/200 ppm

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - N,N-Dimethylformamide

NIOSH: Pocket Guide to Chemical Hazards - Dimethylformamide

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Dimethylformamide. See annual publication for most recent information.
  • EPA Air Toxics Website: N,N-Dimethylformamide. U.S. Environmental Protection Agency Technology Transfer Network.
  • Angerer, J., Göen, T., Krämer, A. and Käfferlein, H.U.: N-methylcarbamoyl adducts at the N-terminal valine of globin in workers exposed to N,N-dimethylformamide. Arch. Toxicol. 72(5): 309-313, 1998.
  • Chang, H.-Y., Shih, T.-S., Guo, Y.-L., Tsai, C.-Y. and Hsu, P.-C.: Sperm function in workers exposed to N,N-dimethylformamide in the synthetic leather industry. Fertil. Steril. 81(6): 1589-1594, 2004.
  • Chang, H.-Y., Tsai, C.-Y., Lin, Y.-Q., Shih, T.-S., and Lin, W.-C.: Total body burden arising from a week's repeated dermal exposure to N,N-dimethylformamide. Occup. Environ. Med. 62(3): 151-156, 2005.
  • Cox, N.H. and Mustchin, C.P.: Prolonged spontaneous and alcohol-induced flushing due to the solvent dimethylformamide. Contact Dermatitis 24(1): 69-70, 1991.
  • Dimethylformamide. IARC Monogr. Eval. Carcinog. Risks Hum. 71(Pt. 2): 545-574, 1999.
  • Käfferlein, H.U., et al.: The use of biomarkers of exposure of N,N-dimethylformamide in health risk assessment and occupational hygiene in the polyacrylic fibre industry. Occup. Environ. Med. 62(5): 330-336, 2005.
  • Mráz, J., Dušková, Š., Gálová, E., Nohová, H. and Brabec, M.: Biological monitoring of N,N-dimethylformamide. Reference value for N-methylcarbamoyl adduct at the N-terminal valine as a biomarker of chronic occupational exposure. Int. Arch. Occup. Environ. Health 75(Suppl.): S93-96, 2002.
  • Pohanish, R.P. (editor): N,N-Dimethylformamide. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 926-928.

Last Updated Date : 12/28/2020