CHLOROFORM (TRICHLOROMETHANE)†

Chemical Identification
Chemical Identification
CAS # 67-66-3
Formula

CHCl₃

Synonyms

methane trichloride; trichloromethane

Physical Properties
Physical Properties
Physical description Colorless liquid with a pleasant odor.
Boiling point 143°F Molecular weight 119.4
Freezing point/melting point -82°F Vapor pressure 160 mmHg
Flash point Vapor density 4.12
Specific gravity 1.48 Ionization potential 11.42 eV
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating 2 NFPA fire rating 0
NFPA reactivity rating 0 NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 0670
Sampling group
Sampler/Sampling media CSC tube (100/50 mg) [SKC 226-01]
Sampling time*

50 min

Sampling volume (TWA)*

10 L

Sampling flow rate (TWA)*

0.2 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments GC-FID
Method reference OSHA 5 (fully validated)
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device Detector tube Detector tube Detector tube
Model/Type Dräger - Chloroform 2/a, 6728861 Gastec 137L Matheson-Kitagawa 8014-152S
Sampling information
(see manufacturer instructions)
10 strokes, approx 1-10 ppm range, uncertainty approx 33% 3-5 strokes, 0.1-27 ppm range, uncertainty 16% for 0.5-2 ppm, 8% for 2-10 ppm 2-4 strokes, approx 20-500 ppm range
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA TLV-TWA

10 ppm [1990]

PEL-TWA

2 ppm (9.78 mg/m³)

PEL-STEL REL-STEL

2 ppm (9.78 mg/m³) [60 minutes]

TLV-STEL PEL-STEL
PEL-C

50 ppm (240 mg/m³)

REL-C TLV-C PEL-C
Skin notation

N

Skin notation

N

Skin notation

N

Skin notation

N

Notes:

See 29 CFR 1910.1000 Table Z-1.

Notes:

CARCINOGEN (Ca): REDUCE EXPOSURE TO LOWEST FEASIBLE CONCENTRATION. See Appendix A

Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH

500 ppm

Carcinogenic classifications: IARC-2B, NIOSH-Ca, NTP-R, TLV-A3, EPA-B2; L; NL Notes:

Ca

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:

--/50 ppm/5000 ppm

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Chloroform

NIOSH: Pocket Guide to Chemical Hazards - Chloroform

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Chloroform. See annual publication for most recent information.
  • EPA Air Toxics Website: Chloroform. U.S. Environmental Protection Agency Technology Transfer Network.
  • Gemma, S., Vittozzi, L. and Testai, E.: Metabolism of chloroform in the human liver and identification of the competent P450s. Drug Metab. Dispos. 31(3): 266-274, 2003.
  • Pohanish, R.P. (editor): Chloroform. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 568-571.

Last Updated Date : 12/21/2020