ISOPHORONE DIISOCYANATE

Chemical Identification
Chemical Identification
CAS # 4098-71-9
Formula

C₁₂H₁₈N₂O₂

Synonyms

IPDI, isocyanic acid, methylene (3,5,5-trimethyl-3,1-cyclohexylene) ester, 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl-isocyanate, isophorone diamine diisocyanate

Physical Properties
Physical Properties
Physical description Colorless to slightly yellow liquid with a pungent odor.
Boiling point Molecular weight 222.3
Freezing point/melting point -76°F Vapor pressure 0.0003 mmHg
Flash point 311°F Vapor density
Specific gravity 1.06 Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating 2 NFPA fire rating 1
NFPA reactivity rating 1 NFPA special instruction W: Reacts violently or explosively with water.
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1539
Sampling group
Sampler/Sampling media Isocyanate Sampling Filter Kit - GFF (37 mm, open-faced) coated with 1 mg 1-(2-pyridyl)piperazine [SLTC103]
Sampling time*

15 min

Sampling volume (TWA)*

15 L

Sampling flow rate (TWA)*

1 L/min

Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments UHPLC
Method reference OSHA 5002 (fully validated)
Notes

Refrigerate coated filters until used. Sample open-faced!!

Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA

0.005 ppm (0.045 mg/m³)

TLV-TWA

0.005 ppm [1985]

PEL-TWA

0.005 ppm (0.045 mg/m³)

PEL-STEL REL-STEL

0.02 ppm (0.180 mg/m³)

TLV-STEL PEL-STEL

0.02 ppm

PEL-C REL-C TLV-C PEL-C
Skin notation

N

Skin notation

Y

Skin notation

N

Skin notation

Y

Notes:

Not established

Notes: Notes: Notes:
Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Not listed Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Isophorone diisocyanate

NIOSH: Pocket Guide to Chemical Hazards - Isophorone diisocyanate

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Isophorone diisocyanate. See annual publication for most recent information.
  • Pohanish, R.P. (editor): Isophorone Diisocyanate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1344-1346.
  • Tinnerberg, H., Skarping, G., Dalene, M. and Hagmar, L.: Test chamber exposure of humans to 1,6-hexamethylene diisocyanate and isophorone diisocyanate. Int. Arch. Occup. Environ. Health 67(6): 367-374, 1995.

Last Updated Date : 04/14/2021