SUBTILISINS

Chemical Identification
Chemical Identification
CAS # 1395-21-7; 9014-01-1
Formula

Mixture

Synonyms

Bacillus subtilis; Bacillus subtilis BPN; Bacillus subtilis Carlsburg; proteolytic enzymes; Subtilisin BPN; Subtilisin Carlsburg [Note: Commercial proteolytic enzymes are used in laundry detergents.]

Physical Properties
Physical Properties
Physical description Light-colored, free-flowing powders.
Boiling point Molecular weight 28,000 (approx)
Freezing point/melting point Vapor pressure 0 mmHg (approx)
Flash point Vapor density
Specific gravity Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.)
Sampling group
Sampler/Sampling media
Sampling time*
Sampling volume (TWA)*
Sampling flow rate (TWA)*
Sampling volume (STEL/Peak/C)*
Sampling flow rate (STEL/Peak/C)*
Analytical method instruments
Method reference
Notes
Special requirements

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
Bulk Method
Bulk Method
On-Site Screening Techniques
On-Site Screening Techniques
Device
Model/Type
Sampling information
(see manufacturer instructions)
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA REL-TWA TLV-TWA PEL-TWA
PEL-STEL REL-STEL

0.00006 mg/m³ [60 minutes]

TLV-STEL PEL-STEL

0.00006 mg/m³

PEL-C REL-C TLV-C

0.00006 mg/m³ [1972]

PEL-C
Skin notation

NA

Skin notation

N

Skin notation

N

Skin notation

N

Notes:

Not established

Notes: Notes: Notes:

Footnote [r]: Compliance with the subtilisins PEL is assessed by sampling with a high volume sampler (600-800 liters per minute) for at least 60 minutes.

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: Notes:
AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Not listed

NIOSH: Pocket Guide to Chemical Hazards - Subtilisins

Literature References

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Subtilisins [1395-21-7; 9014-01-1], as 100% crystalline active pure enzyme. See annual publication for most recent information.

Last Updated Date : 01/12/2021