ENFLURANE

Chemical Identification
Chemical Identification
CAS # 13838-16-9
Formula
 

CHF₂OCF₂CHClF

Synonyms
 

2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane; 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether; ethrane

Physical Properties
Physical Properties
Physical description Clear, colorless liquid with a mild, sweet odor.
Boiling point 134°F Molecular weight 184.5
Freezing point/melting point Vapor pressure 175 mmHg
Flash point Vapor density
Specific gravity 1.52 at 77°F Ionization potential
Lower explosive limit (LEL) Upper explosive limit (UEL)
NFPA health rating NFPA fire rating
NFPA reactivity rating NFPA special instruction
Vapor hazard ratio (VHR)
Historical exceedance percentage
Target organs
Monitoring Methods Used by OSHA
Monitoring Methods Used by OSHA
Analyte code (IMIS no.) 1038 1038
Sampling group
Sampler/Sampling media Anasorb 747 (140/70 mg) [SKC 226-81A] CSC tube (100/50 mg) [SKC 226-01]
Sampling time*
 

 

 

 

Sampling volume (TWA)*
 

12 L

 

10 L

Sampling flow rate (TWA)*
 

0.05 L/min

 

0.1 L/min

Sampling volume (STEL/Peak/C)*
 

 

 

 

Sampling flow rate (STEL/Peak/C)*
 

 

 

 

Analytical method instruments GC-FID GC-FID
Method reference OSHA 103 (fully validated) OSHA 29 (fully validated)
Notes
 

 

 

 

Special requirements
 

 

 

 

* All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details.

Wipe Method
Wipe Method
Sampler/Sampling media
 

 

Bulk Method
Bulk Method
 

 

On-Site Screening Techniques
On-Site Screening Techniques
Device Infrared spectrophotometer Infrared spectrophotometer Organic vapor analyzer
Model/Type Miran 1A & 1B Miran 103
Sampling information
(see manufacturer instructions)
0.03 ppm at 8.9 µm 0-10 ppm at 8.7 µm
Exposure Limits
Exposure Limits
OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
NIOSH REL
Up to 10-hour TWA
(ST) STEL
(C) Ceiling
ACGIH TLV©
8-hour TWA
(ST) STEL
(C) Ceiling
CAL/OSHA PEL
8-hour TWA
(ST) STEL
(C) Ceiling
Peak
PEL-TWA
 

 

REL-TWA
 

 

TLV-TWA
 

75 ppm [1979]

PEL-TWA
 

2 ppm (15 mg/m³)

PEL-STEL
 

 

REL-STEL
 

 

TLV-STEL
 

 

PEL-STEL
 

 

PEL-C
 

 

REL-C
 

2 ppm (15.1 mg/m³) [60 minutes]

TLV-C
 

 

PEL-C
 

 

Skin notation
 

NA

Skin notation
 

N

Skin notation
 

N

Skin notation
 

N

Notes:
 

Not established

Notes:
 

CEILING IS FOR EXPOSURE TO WASTE ANESTHETIC GASES

Notes:
 

 

Notes:
 

 

Health factors:  See NIH-NLM PubChem. IDLH
Carcinogenic classifications: IARC-3, TLV-A4 Notes:
 

 

AIHA emergency response planning guidelines - ERPG-1/ERPG-2/ERPG-3:
 

 

Additional Resources and Literature References
Additional Resources and Literature References

NOAA: CAMEO Chemicals - Enflurane

NIOSH: Pocket Guide to Chemical Hazards - Enflurane

Literature References

 
  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Enflurane. See annual publication for most recent information.

Last Updated Date : 12/28/2020