 |
Chemical Sampling Information: |
|
| Triethanolamine |
|
General Description
Synonyms: Tris(2-hydroxyethyl)amine; Tri(hydroxyethyl)amine; Trolamine; TEA (amino alcohol); Nitrilo-2,2',2''-Triethanol; Triethylolamine; Daltogen
OSHA IMIS Code Number: T185
Chemical Abstracts Service (CAS) Registry Number: 102-71-6
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KL9275000
Chemical Description and Physical Properties: clear, colorless, viscous, hygroscopic liquid with slight ammoniacal odor
molecular formula: C6H15NO3
molecular weight: 149.22
flash point: 179°C
Exposure Limits
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA
Health Factors
Potential symptoms: Irritation of eyes, skin, respiratory tract; cough, sore throat; asthma; allergic contact dermatitis (not common).
Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Respiratory sensitization (asthma) (HE9); Dermatitis (HE3)
Affected organs: Eyes, skin, respiratory system
Notes: 1) OSHA does not have a PEL for triethanolamine. 2) Studies with mice indicate extensive absorption through the skin. 3) Cases of asthma occurred after several years' exposure to heated or vaporized triethanolamine, as in metal-working fluids. 4) Two-year dermal application studies with female B6C3F1 mice (100, 300, 1000 mg/kg, 5 days per week) indicated some evidence of carcinogenic activity based on increased incidences of hepatocellular adenoma. A proposed mechanism for this is the production of a deficiency of choline.
Date Last Revised: 08/17/2004
Literature Basis:
- International Chemical Safety Cards (WHO/IPCS/ILO): Triethanolamine.
- NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: KL9275000: Ethanol, 2,2',2"- nitrilotri-.
- Blum, A. and Lischka, G.: Allergic contact dermatitis from mono-, di- and triethanolamine. Contact Dermatitis 36(3): 166, 1997.
- National Toxicology Program: NTP toxicology and carcinogenesis studies of triethanolamine (Cas No. 102-71-6) in B6C3F1 mice (dermal studies). Nat. Toxicol. Program Tech. Rep. Ser. (518): 5-163, 2004.
- Pohanish, R.P. (editor): Ethanolamines. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1028-1031.
- Savonius, B, Keskinen, H., Tuppurainen, M. and Kanerva, L.: Occupational asthma caused by ethanolamines. Allergy 49(10): 877-881, 1994.
- Stott, W.T., Radtke, B.J., Linscombe, V.A., Mar, M.-H. and Zeisel, S.H.: Evaluation of the potential of triethanolamine to alter hepatic choline levels in female B6C3F1 mice. Toxicol. Sci. 79(2): 242-247, 2004.
- Stott, W.T., Waechter, J.M., Rick, D.L. and Mendrala, A.L.: Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice. Food Chem. Toxicol. 38(11): 1043-1051, 2000.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
-
sampling media: 37 mm Glass Fiber Filter
analytical solvent: Acetone
maximum volume: 120 Liters maximum flow rate: 1.0 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA SLTC In-House File
method classification: Not Validated
* All Trademarks are the property of their respective owners.
|
|
|
|
 |
|
Back to Top
www.osha.gov
