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Chemical Sampling Information |
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| 1,1,1,2-Tetrafluoroethane |
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General Description
Synonyms: Freon 134a; SUVA-134a; HFC-134a
OSHA IMIS Code Number: R225
Chemical Abstracts Service (CAS) Registry Number: 811-97-2
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KI8842500
Chemical Description and Physical Properties: Gas
molecular formula: C2H2F4
molecular weight: 102.03
boiling point: -26.2°C
vapor pressure: 581 kPa @ 25°C
melting point: -101°C
Health Factors
Potential symptoms: Dizziness, drowsiness, dullness; frostbite (on contact with liquid).
Health Effects: Narcosis (HE8)
Affected organs: CNS, skin
Notes:
- OSHA does not have a PEL for 1,1,1,2-tetrafluoroethane
- EPA's inhalation reference concentration (daily inhalational exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for 1,1,1,2-tetra-fluoroethane is 80 mg/m3.
- Because of its use in metered-dose inhalers, 1,1,1,2-tetrafluoroethane has been studied in human volunteers with single-breath inhalation and one-hour exposures to concentrations up to 8000 ppm, which caused no respiratory irritation or adverse effects on pulse, blood pressure, lung function, electrocardiogram or on the CNS.
Date Last Revised: 07/28/2006
Literature Basis:
- International Chemical Safety Cards (WHO/IPCS/ILO): 1,1,1,2-Tetrafluoroethane.
- U.S. EPA Integrated Risk Information System: 1,1,1,2-Tetrafluoroethane (CASRN 811-97-2).
- Emmen, H.H., et al.: Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3,3-heptafluoropropane) following whole-body exposure. Regul. Toxicol. Pharmacol. 32(1): 22-35, 2000.
- Pike, V.W., et al.: Disposition of inhaled 1,1,1,2-tetrafluoroethane (HFA134A) in healthy subjects and in patients with chronic airflow limitation. Measurement by 18F-labeling and whole-body γ-counting. Drug. Metab. Dispos. 23(8): 832-839, 1995.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Anasorb CMS (150/75 mg sections)
analytical solvent: (60:40) DMF:Carbon Disulfide
maximum volume: 10 Liters maximum flow rate: 0.05 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA SLTC In-House File
method classification: Not Validated
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