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Subtilisins

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General Description
    Synonyms: Bacillus subtilis; Bacillus subtilis BPN; Bacillus subtilis Carlsburg; Subtilisin BPN; Subtilisin Carlsburg [Note: Commercial proteolytic enzymes are used in laundry detergents.]

    OSHA IMIS Code Number: 9220

    Related Chemical Abstracts Service (CAS) Registry Numbers: 1395-21-7 (BPN); 9014-01-1 (Carlsburg)

    NIOSH, Registry of Toxic Effects (RTECS) Identification Number: CO9450000 (BPN) and CO9550000 (Carlsburg)

    NIOSH Pocket Guide to Chemical Hazards, Subtilisins: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
    American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.00006 mg/m3 Ceiling (Listed under Subtilisins, as crystalline active enzyme)

    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.00006 mg/m3 STEL (60 Minutes)
Health Factors
    Health Effects: Respiratory allergy (asthma) (HE9); Lung damage (HE10); Irritation-Skin---Mild (HE16)
Monitoring Methods used by OSHA
    Laboratory Sampling/Analytical Method:

    Bulk method: Submit 1 gram pure bulk material.
    note: The only analysis for Subtilisins currently performed at SLTC is its content in bulk material samples. OSHA staff should call the SLTC for guidance.

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