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Nicotine
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General Description
    Synonyms: 3-(1-Methyl-2-pyrrolidyl)pyridine

    OSHA IMIS Code Number: 1855

    Chemical Abstracts Service (CAS) Registry Number: 54-11-5

    NIOSH, Registry of Toxic Effects (RTECS) Identification Number: QS5250000

    Department of Transportation Regulation Number (49 CFR 172.101) and guide [2008 Emergency Response Guidebook, 2.5 MB PDF]: 1654 151

    NIOSH Pocket Guide to Chemical Hazards, Nicotine: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
    OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 0.5 mg/m3 TWA (Skin)

    OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 0.5 mg/m3 TWA; Skin

    OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 0.5 mg/m3 TWA; Skin

    American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.5 mg/m3 TWA; Skin

    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.5 mg/m3 TWA; Skin
Health Factors
    NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 5 mg/m3

    Potential symptoms: Nausea, salivation, abdominal pain, vomiting, diarrhea; headache, dizziness, hearing, visual disturbance; confusion, lassitude (weakness, exhaustion), incoordination; cardiac arrhythmias; convulsions, dyspnea (breathing difficulty); in animals: teratogenic effects

    Health Effects: Acute systemic toxicity (HE4); CNS damage (HE7) Suspect teratogen (HE5)

    Affected organs: central nervous system, cardiovascular system, lungs, gastrointestinal tract, reproductive system
Monitoring Methods used by OSHA
    Laboratory Sampling/Analytical Method:

    • sampling media: XAD-4 Tube (80/40 mg sections)
      maximum volume: 100 Liters   maximum flow rate: 1.0 L/min
      current analytical method: Gas Chromatography; GC/NPD
      method reference: NIOSH Analytical Method (NIOSH 2551) [28 KB, PDF, 4 pages]
      method classification: Partialy Validated

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