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Chemical Sampling Information (CSI)
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General Description

Synonyms: MIC; Isocyanatomethane

OSHA IMIS Code Number: 1773

Chemical Abstracts Service (CAS) Registry Number: 624-83-9

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: NQ9450000; 44212

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: UN2480 Poison, Flammable Liquid

Chemical Description and Physical Properties:

Clear liquid.
molecular weight: 57.05
vapor pressure: 348 mm
boiling point: 59.6°C
melting point: < -80°C

Incompatibilities: water, rapid reaction in presence of acid, alkali, amine; iron, tin, copper, their salts, other catalysts

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 0.02 ppm, 0.05 mg/m3 (Skin)
Construction Industry: 0.02 ppm, 0.05 mg/m3 TWA (Skin)

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.02 ppm, 0.047 mg/m3 TWA (Skin)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.02 ppm TWA (Skin)

Health Factors

Potential Symptoms: Eye, nose, throat irritation; coughing, secretions, chest pain, dyspnea, asthma; eye, skin injury; In animals: pulmonary edema

Health Effects: Asthma (HE9); Lung edema (HE11) Irritation-Eye, Nose, Throat, Skin-Marked (HE14)

Affected Organs: Respiratory system, eyes, skin

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Coated XAD-7 Tube. Coating is 0.3 mg 1-(2-Pyridyl)Piperazine.
    analytical solvent: Acetonitrile
    maximum volume: 15 Liters
    maximum flow rate: 0.05 L/min
    current analytical method: High Performance Liquid Chromatography; HPLC/UV/FLU
    method reference: 2 (OSHA 54)
    sampling and analytical error: 0.13
    method classification: Fully Validated
    note: OSHA personnel may obtain sample tubes from SLTC. Sampling tubes should be stored under refrigeration.

Conditions: Acetonitrile desorption; Zorbax CN; 20%-25% acetonitrile 75% - 80% water (with 1.54 g ammonium acetate per liter); adjust pH to 5.1-6.5 with acetic acid; 1 mL/min; UV = 254; ex 240 nm; em 370; Retention time, 7.5-11 min; DL 0.15 ng/inj; C/P DB/DL 1/85

Secondary Laboratory Sampling/Analytical Method (SAM2):

  • device: Instrumentation
    company: Infrared Spectrophotometer
    part #: MIRAN 1A & 1B
    range: 0.1 ppm @ 4.4 um
    method classification: Mfg
  • device: Instrumentation
    company: PID
    part #: Photoionization Detector
    method classification: Mfg

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