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Chemical Sampling Information (CSI)
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General Description

Synonyms: Amyl methyl ketone; N-Amyl methyl ketone; 2-Heptanone; MAK

OSHA IMIS Code Number: 1675

Chemical Abstracts Service (CAS) Registry Number: 110-43-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: MJ5075000

Department of Transportation Regulation Number (49 CFR 172.101) and 2012 Emergency Response Guidebook [4 MB PDF, 392 pages]: 1110 127

NIOSH Pocket Guide to Chemical Hazards - Methyl (n-amyl) ketone: Chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits and Health Effects

Exposure Limit

Limit Values

HE Codes

Health Factors and Target Organs

OSHA Permissible Exposure Limit (PEL) - General Industry
See 29 CFR 1910.1000 Table Z-1

100 ppm
(465 mg/m3) TWA

HE8

Narcosis
HE15 Mucous membrane irritation

OSHA PEL - Construction Industry
See 29 CFR 1926.55 Appendix A

100 ppm
(465 mg/m3) TWA

HE8

Narcosis
HE15 Mucous membrane irritation

OSHA PEL - Shipyard Employment
See 29 CFR 1915.1000 Table Z-Shipyards

100 ppm
(465 mg/m3) TWA

HE8

Narcosis
HE15 Mucous membrane irritation

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)

100 ppm
(465 mg/m3) TWA

HE8

Narcosis
HE15 Mucous membrane irritation

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2001)

50 ppm
(233 mg/m3) TWA

HE15

Eye and skin irritation
CAL/OSHA PEL 50 ppm
(235 mg/m3) TWA

HE15

Eye and skin irritation

National Toxicology Program (NTP) carcinogenic classification: Not listed

International Agency for Research on Cancer (IARC): Not listed

U.S. Environmental Protection Agency (EPA) carcinogenic classification: Not listed

EPA Inhalation Reference Concentration (RfC): Not established

Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established

NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: 800 ppm

Notes on Other Potential Health Effects and Hazards

  1. Explosive vapor/air mixtures may be formed above 48°C (NIOSH/IPCS 1996).

Date last revised: 09/06/2012

Literature Basis

Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: (99:1) Carbon Disulfide:Methanol
    maximum volume: 25 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1301 [25 KB PDF, 5 pages])
    method classification: Fully Validated

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