Chemical Sampling Information
	Isobutyl Isobutyrate
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: 2-Methylpropyl Isobutyrate; 2-Methylpropyl 2-Methylpropanoate; 2-Methylpropyl 2-Methylpropionate; Isobutyric Acid, Isobutyl Ester; OSHA IMIS Code Number: 1537 Chemical Abstracts Service (CAS) Registry Number: 97-85-8 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: NQ5250000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2528 130 [27 KB, PDF] Chemical Description and Physical Properties: clear liquid molecular formula: C8H16O2 molecular weight: 144.21 boiling point: 148°C flash point: 37°C (open cup) Health Factors Potential symptoms: Irritation of eyes, respiratory tract, skin; drowsiness; dry, cracked skin, dermatitis (with prolonged or repeated skin contact). Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8) Affected organs: Eyes, skin, respiratory system, CNS Notes: OSHA does not have a PEL for isobutyl isobutyrate. Isobutyl isobutyrate is listed among FDA’s “food additives permitted for direct addition to food for human consumption” (21 CFR 172.515). The NOAEL was reported to be 1000 mg/kg/day, the highest dose tested in rats given isobutyl isobutyrate in corn oil orally 7 days/week for 18 weeks. Date Last Revised: 09/12/2006 Literature Basis: Drake, J.J., Butterworth, K.R., Gaunt, I.F. and Grasso, P.: Short-term toxicity study of isobutyl isobutyrate in rats. Food Cosmet. Toxicol. 16(4): 337-342, 1978. Eastman Product Safety and Health: Material Safety Data Sheet: Propanoic acid, 2-methyl-, 2-methylpropyl ester (revised 08/26/2004), 6 pp. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) analytical solvent: (99:1) Carbon Disulfide:DMF maximum volume: 10 Liters   maximum flow rate: 0.2 L/min current analytical method: Gas Chromatography; GC/FID method reference: OSHA Analytical Method (OSHA PV2090) method classification: Partially Validated All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.