||Chemical Sampling Information
Synonyms: 2-Methylpropyl Isobutyrate; 2-Methylpropyl 2-Methylpropanoate; 2-Methylpropyl 2-Methylpropionate; Isobutyric Acid, Isobutyl Ester;
OSHA IMIS Code Number: 1537
Chemical Abstracts Service (CAS) Registry Number: 97-85-8
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: NQ5250000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2528 130 [27 KB, PDF]
Chemical Description and Physical Properties: clear liquid
molecular formula: C8H16O2
molecular weight: 144.21
boiling point: 148°C
flash point: 37°C (open cup)
Potential symptoms: Irritation of eyes, respiratory tract, skin; drowsiness; dry, cracked skin, dermatitis (with prolonged or repeated skin contact).
Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8)
Affected organs: Eyes, skin, respiratory system, CNS
- OSHA does not have a PEL for isobutyl isobutyrate.
- Isobutyl isobutyrate is listed among FDA’s “food additives permitted for direct addition to food for human consumption” (21 CFR 172.515).
- The NOAEL was reported to be 1000 mg/kg/day, the highest dose tested in rats given isobutyl isobutyrate in corn oil orally 7 days/week for 18 weeks.
Date Last Revised: 09/12/2006
Monitoring Methods used by OSHA
- Drake, J.J., Butterworth, K.R., Gaunt, I.F. and Grasso, P.: Short-term toxicity study of isobutyl isobutyrate in rats. Food Cosmet. Toxicol. 16(4): 337-342, 1978.
- Eastman Product Safety and Health: Material Safety Data Sheet: Propanoic acid, 2-methyl-, 2-methylpropyl ester (revised 08/26/2004), 6 pp.
Laboratory Sampling/Analytical Method:
sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: (99:1) Carbon Disulfide:DMF
maximum volume: 10 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA PV2090)
method classification: Partially Validated
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