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Chemical Sampling Information (CSI)
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General Description

Synonyms: Isobutyl ester of acetic acid; 2-Methylpropyl acetate; 2-Methylpropyl ester of acetic acid; beta-Methylpropyl ethanoate

OSHA IMIS Code Number: 1534

Chemical Abstracts Service (CAS) Registry Number: 110-19-0

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AI4025000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1213 129

NIOSH Pocket Guide to Chemical Hazards, Isobutyl Acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Z-1 Table -- 150 ppm, 700 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A -- 150 ppm, 700 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 150 ppm, 700 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 150 ppm, 713 mg/m3 TWA

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 150 ppm, 700 mg/m3 TWA

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,300 ppm [LEL]

Potential Symptoms: Irritation of eyes, skin, upper respiratory system; cough, sore throat; headache, dizziness, drowsiness; anesthesia; in animals: narcosis. INGES. ACUTE: nausea

Health Effects: Irritation-Eye, Nose, Throat---Moderate (HE15); Narcosis (HE8); Explosive, Flammable (HE18)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:
  1. Vapor/air mixtures may be explosive. The IDLH is 10% of the lower explosive limit (1.3%).
  2. Listed among FDA's "food additives permitted for direct addition to food for human consumption" (21 CFR 172.515)
Date Last Revised: 02/08/2006

Literature Basis:
  • NIOSH Pocket Guide to Chemical Hazards: Isobutyl Acetate.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Isobutyl acetate.
  • Pohanish, R.P. (editor) Butyl Acetates. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 392-395.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon Disulfide
    maximum volume: 12 Liters   
    maximum flow rate:     0.05 L/min (TWA)
    maximum volume: 0.75 Liter   
    maximum flow rate: 0.05 L/min (STEL)
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 1009)
    method classification: Fully Validated

  • sampling media: Diffusive Sampler:
    • 3M 3520 Organic Vapor Monitor;
    • SKC 575-002 Passive Sampler
    analytical solvent: Carbon Disulfide
    minimum time: 15 to 240 Minutes
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA 1009)
    method classification: Fully Validated
    note: Persons using diffusive samplers to monitor workplace air must ensure that the sampling devices are properly closed before transporting such devices to the laboratory for analysis. The device will continue to sample until properly closed. Diffusive sampler accessories used for analysis of samplers must be included with transported samples. Persons using such devices must provide sampling-site station barometric pressure and temperature to the analytical laboratory to improve accuracy of sampling results.

  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon Disulfide
    alternate analytical solvent: (99:1) Carbon Disulfide: Dimethylformamide
    alternate analytical solvent: (95:5) Methylene Chloride: Methanol
    maximum volume: 10 Liters   
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1450 [107 KB PDF, 6 pages])
    method classification: Fully Validated
    note: Samples should be refrigerated as soon as possible after sampling and sent cold to the laboratory.
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