Chemical Sampling Information
	Ethyl 2-Cyanoacrylate
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase ]   Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number   General Description Synonyms: 2-Cyanoacrylate acid, Ethyl ester; ECA; Ethyl cyanoacrylate; Ethyl alpha-cyanoacrylate; 2-Propenoic acid, 2-cyano, ethyl ester OSHA IMIS Code Number: E108 Chemical Abstracts Service (CAS) Registry Number: 7085-85-0 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: UD3330050 Chemical Description and Physical Properties: Clear colorless liquid with irritating, sweet, ester-like odor. molecular formula: C6H7NO2 molecular weight: 125.14 boiling point: 54-56°C (2.6-3.0 mm Hg) vapor pressure: 0.17 mm Hg @ 20°C Exposure Limits American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.2 ppm, 1 mg/m3 TWA (TLV listed under Ethyl Cyanoacrylate) Health Factors Potential symptoms: Irritation of eyes. Skin, upper respiratory tract; lacrimation, rhinorrhea; skin sensitization, dermatitis. Health Effects: : Allergic contact dermatitis (HE3); Irritation-Eyes, Nose, Throat, Skin---Marked (HE14). Affected organs: Eyes, skin, nails Notes: OSHA does not have a PEL for ethyl 2-cyanoacrylate. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (a measure of upper respiratory irritation not necessarily predictive of damage) was calculated to be 0.7 ppm in both dry air and at 50% humidity. Measurement of airborne ethyl 2-cyanoacrylate at a manufacturing plant indicated some exposures above 0.7 ppm, but these were of short duration (<15 minutes). Case reports of asthma in workers exposed to cyanoacrylates, including ethyl 2-cyanoacrylate, have been reviewed (Goodman et al., 2000). From the information provided, it was not possible to determine whether these cases were due to sensitization or irritation. Above 75°, explosive vapor/air mixtures may be formed. Date Last Revised: 06/08/2006 Literature Basis: International Chemical Safety Cards (WHO/IPCS/ILO): Ethyl 2-cyanoacrylate. Bruze, M., Björkner, B. and Lepoittevin, J.-P.: Occupational contact dermatitis from ethyl cyanoacrylate. Contact Dermatitis 32(3): 156-159, 1995. Constandt, L., Hecke, E.V., Naeyaert, J.M. and Goossens, A.: Screeing for contact allergy to artificial nails. Contact Dermatitis 52(2): 73-77, 2005. Gagnaire, F., Marignac, B., Morel, G., Nunge, H. and Grossmann, S.: Sensory irritation due to methyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate in mice. Ann. Occup. Hyg. 47(4): 297-304, 2003. Goodman, M., et al.: Epidemiologic study of pulmonary obstruction in workers occupationally exposed to ethyl and methyl cyanoacrylate. J. Toxicol. Environ. Health A 59(3): 135-163, 2000. Paustenbach, D., Burke, M.L., Shum, M. and Kalmes, R.: Airborne concentrations of ethyl and methyl cyanoacrylate in the workplace. AIHAJ 62(1): 70-79, 2001. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Coated XAD-7 Tube (80/40 mg sections, 20/60 mesh); coating is Phosphoric Acid. analytical solvent: (0.2:99.8) Phosphoric Acid:Acetonitrile maximum volume: 12 Liters   maximum flow rate: 0.1 L/min current analytical method: High Performance Liquid Chromatography; HPLC/UV method reference: OSHA Analytical Method (OSHA 55) method classification: Fully Validated note: Samples must be kept at reduced temperature and shipped to lab cold. All Trademarks are the property of their respective owners.