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Chemical Sampling Information |
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| Dipropylene Glycol Methyl Ether |
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General Description
Synonyms: (2-Methoxymethylethoxy)propanol; bis-(2-Methoxypropyl) ether; DPGME; Dipropylene glycol monomethyl ether; Dowanol® 50B
OSHA IMIS Code Number: 1014
Chemical Abstracts Service (CAS) Registry Number: 34590-94-8
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: JM1575000
NIOSH Pocket Guide to Chemical Hazards, Dipropylene Glycol Methyl Ether: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 100 ppm, 600 mg/m3 TWA; Skin
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 100 ppm, 600 mg/m3 TWA; Skin
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 100 ppm, 600 mg/m3 TWA; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 100 ppm, 606 mg/m3 TWA; 150 ppm, 909 mg/m3 STEL; Skin (TLV listed under (2-Methoxymethylethoxy)propanol (DPGME))
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 100 ppm, 600 mg/m3 TWA; 150 ppm, 900 mg/m3 STEL; Skin
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 600 ppm
Potential symptoms: Eye, nose irritation; cough; lassitude (weakness, exhaustion), dizziness, drowsiness, headache; dry skin
Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Slight Narcosis (HE8)
Affected organs: Eyes, respiratory system, CNS
Notes:
- Above 74ºC, explosive vapor/air mixtures of dipropylene glycol methyl ether may be formed.
- A good correlation was found between inhalational exposure of floor lacquerers to DPGME and its excretion in urine during an 8-hour shift.
- Rats given 14C-labeled DPGME excreted in their urine unchanged DPGME, as well as propylene glycol methyl ether, dipropylene glycol, propylene glycol, and glucuronide and sulfate conjugates of DPGME. More than ¼ of the dose was expired as CO2 within 48 hours.
- Exposure of rats and rabbits to as much as 200 ppm DPGME 6 hours/day, 5 days/ week for 13 weeks, and exposure of pregnant animals to as much as 300 ppm for days 7-19 (rabbits) or 6-15 (rats) of gestation, was reported to have no adverse effects in these animals or their offspring.
- Exposure to DPGME may also occur by absorption through the skin.
- Topical exposure of rats to as much as 1000 mg/kg 5 days/week for 4 weeks was reported to have no adverse effects in these animals.
- A study of eye irritation in rabbits and human volunteers indicated that DPGME also caused a transient increase in intraocular tension. A 40-µl droplet of 20% (v/v.) aqueous DPGME increased intraocular tension by 12-50%, which returned to baseline tension within an hour in most (9/10) volunteers.
Date Last Revised: 05/04/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Dipropylene Glycol Methyl Ether.
- International Chemical Safety Cards (WHO/IPCS/ILO): Dipropyleneglycol monomethyl ether.
- Ballantyne, B.: Local ophthalmic effects of dipropylene glycol monomethyl ether. J. Toxicol. Cut. Ocular Toxicol. 2(4-5): 229-242, 1983-84.
- Breslin, W.J., Cieszlak, F.S., Zablotny, C.L., Corley, R.A., Verschuuren, H.G. and Yano, B.L.: Evaluation of the developmental toxicity of inhaled dipropylene glycol monomethyl ether (DPGME) in rabbits and rats. Occup. Hyg. 2: 161-170, 1996.
- Fairhurst, S., Knight, R., Marrs, T.C., Scawin, J.W., Spurlock, M.S. and Swanston, D.W.: Percutaneous toxicity of ethylene glycol monomethyl ether and of dipropylene glycol monomethyl ether in the rat. Toxicology 57(2): 209-215, 1989.
- Laitinen, J., Liesivuori, J. and Harvima, R.: Evaluation of exposure to 1-alkoxy-2-propanols and 1-(2-methoxy-1-methylethoxy)-2-propanol by the analysis of the parent compounds in urine. Toxicol. Lett. 162(2-3): 186-194, 2006.
- Landry, T.D. and Yano, B.L.: Dipropylene glycol monomethyl ether: a 13-week inhalation toxicity study in rats and rabbits. Fundam. Appl. Toxicol. 4(4): 612-617, 1984.
- Miller, R.R., Hermann, E.A., Calhoun, L.L., Kastl, P.L. and Zakett, D.: Metabolism and disposition of dipropylene glycol monomethyl ether (DPGME) in male rats. Fundam. Appl. Toxicol. 5(4): 721-726, 1985.
- Pohanish, R.P. (editor): Dipropylene Glycol Methyl Ether. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 982-983.
- Venier, M., Adami, G., Larese, F., Maina, G. and Renzi, N.: Percutaneous absorption of 5 glycol ethers through human skin in vitro. Toxicol. In Vitro 18(5): 665-671, 2004.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: (95:5) Methylene Chloride:Methanol
maximum volume: 10 Liters maximum flow rate: 0.1 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA 101)
method classification: Fully Validated
Wipe Sampling Method:
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sampling media: Charcoal pad
note: Seal in glass vial for shipment
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