||Chemical Sampling Information
Synonyms: Di-n-propyl disulfide; Propyl disulfide; Propyl disuphide
OSHA IMIS Code Number: D626
Chemical Abstracts Service (CAS) Registry Number: 629-19-6
Chemical Description and Physical Properties: colorless to pale yellow odorous liquid
molecular formula: C6H14S2
molecular weight: 150.31
boiling point: 195-196°C
flash point: 66.1°C
melting point: -86°C
Potential symptoms: Irritation of eyes, respiratory tract, skin, and digestive tract.
Health Effects: No health effect studies in humans were found. Potential Irritation-Eye, Nose, Throat---Marked (HE14).
Affected organs: Eyes, respiratory system, skin
- OSHA does not have a PEL for dipropyl disulfide (DPDS), and its toxicological properties (e.g., acute LD50, LC50, toxicokinetics, and chronic effects in animals) have not been fully investigated.
- The odor detection threshold for DPDS has been reported to be 0.13 mg/m3, and it may be a significant component of the aroma of slices of leek and onion.
- Studies with isolated perfused rat livers indicated metabolism of DPDS to propyl mercaptan, propylglutathione sulfide methylpropyl sulfide, and methylpropyl sulfone. Pretreatment of rats with DPDS increased its own metabolism, possibly by the induction of cytochrome P450 2B1/2. It also induced microsomal epoxide hydrolase, glutathione S-transferase, and UDP-glucuronosyltransferase activities in liver.
Date Last Revised: 09/12/2006
Monitoring Methods used by OSHA
- Acros Organics.: Material Safety Data Sheet: Propyl disulfide, 99%.
- Guyonnet, D., Siess, M.H., Le Bon, A.M. and Suschetet, M.: Modulation of phase II enzymes by organosulfur compounds from allium vegetables in rat tissues. Toxicol. Appl. Pharmacol. 154(1): 50-58, 1999.
- Nielsen, G.S. and Poll, L.: Determination of odor active aroma compounds in freshly cut leek (Allium ampeloprasum Var. bulga) and in long-term stored frozen unblanched and blanched leek slices by gas chromatography olfactometry analysis. J. Agric. Food Chem. 52(6): 1642-1646, 2004.
- O’Neill, D.H. and Phillips, V.R.: A review of the control of odour nuisance from livestock buildings: Part 3. Properties of the odorous substances which have been identified in livestock wastes or in the air around them. J. Agric. Eng. Res. 53(1): 23-50, 1992.
- Teyssier, C. and Siess, M.H.: Metabolism of dipropyl disulfide by rat liver phase I and phase II enzymes and by isolated perfused rat liver. Drug Metab. Dispos. 28(6): 648-654, 2000.
Laboratory Sampling/Analytical Method:
sampling media: Chromosorb 106 Tube (100/50 mg sections, 60/80 mesh)
analytical solvent: Trichloroethylene
maximum volume: 10 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FPD
method reference: OSHA Analytical Method (OSHA PV2086)
method classification: Partially Validated
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