Chemical Sampling Information
	m-Dichlorobenzene
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: 1,3-Dichlorobenzene; m-Dichlorobenzol; m-Phenylene dichloride OSHA IMIS Code Number: D149 Chemical Abstracts Service (CAS) Registry Number: 541-73-1 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: CZ4499000 Chemical Description and Physical Properties: colorless liquid molecular formula: C6H4Cl2 molecular weight: 147.00 boiling point: 173°C flash point: 63°C closed cup melting point: -24.8°C vapor pressure: 0.286 kPa @ 25°C Potentially hazardous incompatibilities: reacts violently with aluminium Health Factors International Agency for Research on Cancer (IARC) carcinogenic classification: Group 3, not classifiable as to its carcinogenicity to humans [134 KB, PDF] Environmental Protection Agency (EPA) carcinogenic classification: Group D, not classifiable as to human carcinogenicity Potential symptoms: Irritation of eyes, nose, throat, skin; cough, sore throat; drowsiness, nausea, vomiting; skin blisters; in animals: liver, kidney damage; INGES. ACUTE: Burning sensation; nausea, vomiting, diarrhea. Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Liver damage (HE4) Affected organs: Eyes, skin, respiratory system, liver Notes: OSHA does not have a PEL for m-dichlorobenzene. Explosive vapor/air mixtures of m-dichlorobenzene may be formed at temperatures above 63°C. Urinary metabolites of m-dichlorobenzene in rats include 2,4- and 3,5-dichlorophenyl methyl sulfoxides and methyl sulfones, as well as mercapturic acid derivatives. The hepatotoxicity of m-dichlorobenzene may be due to production of reactive metabolites that bind covalently to liver proteins, as well as to oxidative stress from the intracellular depletion of reduced glutathione (GSH). Hepatotoxicity in rats is markedly increased by pretreatment with phenobarbital to induce metabolizing enzymes. Date Last Revised: 03/28/2007 Literature Basis: International Chemical Safety Cards (WHO/IPCS/ILO): 1,3-Dichlorobenzene. U.S. EPA Integrated Risk Information System: 1,3-Dichlorobenzene (CASRN 541-73-1). Kimura, R., Sano, H., Itagaki, K., Kogure, T., Sato, M. and Murata, T.: Identification of sulfer-containing metabolites of m-dichlorobenzene and their disposition and relationship with glutathione in rats. J. Pharmacobiodyn. 7(4): 234-245, 1984. McCauley, P.T., Robinson, M., Daniel, F.B. and Olson, G.R.: Toxicity studies of 1,3-dichlorobenzene in Sprague-Dawley rats. Drug Chem. Toxicol. 18(2-3): 201-221, 1995. No authors listed: Dichlorobenzenes. IARC Monogr. Eval. Carcinog. Risks Hum. 73: 223-276, 1999. [134 KB, PDF] Pohanish, R.P. (editor): Dichlorobenzenes. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 799-804. Stine, E.R., Gunawardhana, L. and Sipes, I.G.: The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer specific and strain-specific differential toxicity. Toxicol. Appl. Pharmacol. 109(3): 472-481, 1991. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) analytical solvent: Carbon Disulfide maximum volume: 10 Liters   maximum flow rate: 0.2 L/min current analytical method: Gas Chromatography; GC/FID method reference: OSHA modified NIOSH Analytical Method (NIOSH 1003) [113 KB, PDF] method classification: Partially Validated All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.