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Safety and Health Topics: |
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| Chloramine-T |
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General Description
Synonyms: Sodium p-Toluenesulfochloramine; para-Toluene Chlorosulfonamide Acid; Chloramine T Trihydrate;
n-Sodium, n-chloro, -para-toluene Sulfonamide;
Sodium p-Toluenesulfonchloramide Trihydrate
OSHA IMIS Code Number: C327
Chemical Abstracts Service (CAS) Registry Number: 127-65-1
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: XT5616800
Chemical Description and Physical Properties: White or slightly yellow crystals or powder, slight chlorine odor. Soluble in water, insoluble in benzene, chloroform and ether. Decomposes slowly in air, liberating chlorine. Decomposes violently at 130°C
molecular formula: C7 H8 Cl N O2 SNa
molecular weight: 228.66
Health Factors
Potential symptoms: Eye irritation, pain, conjunctivitis; burning sensation, coughing, wheezing, laryngitis, sore throat; rhinitis; dyspnea (shortness of breath), bronchitis, pneumonitis, possible pulmonary edema; allergic asthma; skin redness, itching, pain; nausea, vomiting, diarrhea.
Health Effects: Respiratory sensitization---asthma (HE9); SK IRR: allergic urticaria; INGES ACUTE: gastrointestinal irritation.
Affected organs: Eyes, respiratory system, skin
Notes: 1) Approved in Europe as an antiseptic for many medical, dental, and veterinary uses, although major market in U.S. is use in whirlpool baths. 2) FDA approval of chloramine-T for use in aquaculture (fish farming) in the U.S. is being sought (INAD #8086).
Date Last Revised: 06/13/2003
Literature Basis:
- Haneke, K.E.: Chloramine-T [127-65-1] and metabolite p-toluenesulfonamide [70-55-3]: Review of toxicological literature. February 2002, 76 pp.
- (rhinitis)
Piirilä, P., Hodgson, U., Estlander, T., Keskinen, H., Saalo, A., Voutilainen, R. and Kanerva, L.: Occupational respiratory hypersensitivity in dental personnel. Int. Arch. Occup. Environ. Health 75: 209-216, 2002.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
sampling media: Polyvinylchloride (PVC) Filter (37mm)
analytical solvent: Deionized Water
maximum volume: 100 Liters maximum flow rate: 1 L/min
current analytical method: High Performance Liquid Chromatograph; HPLC/UV
method reference: OSHA Manual of Analytical Methods (OSHA In-House File)
method classification: Not Validated
note: Protect samples from light.
analytical condition: Column: CN; Mobile Phase: 70:30:0.2 H2O:Acetonitrile:H3PO4; Detector: UV-254nm
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| Revised: 02 September 2003 |
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