Synonyms: butyl cyanoacrylate; n-butyl cyanoacrylate; 2-cyano-2-propenoic acid butyl ester; enbucrilate

OSHA IMIS Code Number: B444

Chemical Abstracts Service (CAS) Registry Number: 6606-65-1

Chemical Description and Physical Properties:

Clear colorless liquid with a sharp, irritating pungent odor. Insoluble in water.
molecular formula: C₈H₁₁NO₂
molecular weight: 153.18
boiling point: 68°C
density: 0.989 @ 20°C
vapor pressure: <0.5 mm @ 20°C
flash point: >80°C (closed cap)

Incompatibilities: Strong Oxidizing Agents; Strong Acids; Strong Bases; Glass; Highly reactive in water - bonds in seconds.

Potential Symptoms: Eye, nose, and throat irritation; coughing; wheezing; laryngitis; shortness of breath

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); CNS effects (HE7)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:

1. OSHA does not have a PEL for n-butyl-2-cyanoacrylate.
2. n-Butyl-2-cyanoacrylate is used as a medical glue and is a component of an FDA-approved system for the embolization of cerebral arteriovenous malformations prior to their surgical treatment

Date Last Revised: 01/18/2007

Literature Basis: No authors indicated: TRUFILL® n-Butyl Cyanoacrylate (n-BCA) Liquid Embolic System -- P990040 (Issued September 25, 2000). U.S. Food and Drug Administration Center for Devices and Radiologic Health.

Laboratory Sampling/Analytical Method:

• sampling media: Coated XAD-7 Tube (80/40 mg sections, 20/60 mesh); coating is Phosphoric Acid.
  analytical solvent: 0.2% (v/v) Phosphoric Acid in Acetonitrile
  maximum volume: 12 Liters
  maximum flow rate: 0.1 L/min
  current analytical method: High Performance Liquid Chromatography; HPLC/UV
  method reference: OSHA SLTC In-House File
  method classification: Not Validated
  note: Samples must be kept at reduced temperature and shipped to lab cold.

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