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Safety and Health Topics: |
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| Arsine |
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General Description
Synonyms: Hydrogen arsenide; Arsenic trihydride
OSHA IMIS Code Number: 0270
Chemical Abstracts Service (CAS) Registry Number: 7784-42-1
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: CG6475000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2188 119
NIOSH Pocket Guide to Chemical Hazards, Arsine: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 0.05 ppm, 0.2 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 0.05 ppm, 0.2 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.05 ppm, 0.16 mg/m3 TWA
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.002 mg/m3 Ceiling (15 min); Potential Carcinogen
Health Factors
International Agency for Research on Cancer (IARC) carcinogenic classification: Arsenic and Arsenic Compounds - Group 1, carcinogenic to humans
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 3 ppm
Potential symptoms: Headaches; malaise, weakness, dizziness; dyspnea; abdomen and back pain; nausea, vomiting, diarrhea; bronze skin; hematuria (hemoglobin in urine); jaundice, liver enlargement; fever, tachypnea, tachycardia, anemia, hyperkalemia, electrocardiographic changes; peripheral neuropathy (focal anesthesia and paresthesia); agitation, disorientation, hallucinations; (carcinogenic)
Health Effects: Acute Systemic Toxicity - hemolysis, renal failure, heart failure (HE4); Nervous System Disturbances - peripheral nerve degeneration (HE7)
Affected organs: Blood, kidneys, liver, heart
Date Last Revised: 05/07/2003
Literature Basis:
- Klimecki, W.T. and Carter, D.E.: Arsine toxicity: chemical and mechanistic implications. J. Toxicol. Environ. Health 46 : 399-409, 1995.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
maximum volume: 10 Liters minimium volume: 1.0 Liters
maximum flow rate: 0.2 L/min
current analytical method: Atomic Absorption Spectroscopy; AAS/GF
method reference: NIOSH Manual of Analytical Methods (NIOSH 6001)
method classification: Fully Validated
On-Site Sampling Techniques/Methods:
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device: Detector Tube
manufacturer: Dräger
model/type: Arsine 0.05/a, order no. CH 25001
sampling information: 20 strokes
upper measurement limit: 3.0 ppm
detection limit: approximately 0.03 ppm
overall uncertainty: 25-33%
method reference: on-site air secondary (manufacturer)
- device: Detector Tube
manufacturer: Matheson-Kitagawa
model/type: 8014-140SA
sampling information: follow manufacturer's instructions
upper measurement limit: 160 ppm
detection limit: approximately 5 ppm
overall uncertainty: unknown
method reference: on-site air secondary (manufacturer)
- device: Detector Tube
manufacturer: Matheson-Kitagawa
model/type: 8014-121U
sampling information: follow manufacturer's instructions
upper measurement limit: 2.0 ppm
detection limit: approximately 0.05 ppm
overall uncertainty: unknown
method reference: on-site air secondary (manufacturer)
- device: Detector Tube
manufacturer: Gastec
model/type: 19LA
sampling information: 1 to 10 strokes
upper measurement limit: 10 ppm
detection limit: 0.02 ppm
overall uncertainty: 16.4% for 0.1 to 0.5 ppm, 8.2% for 0.5 to 1.5 ppm
method reference: on-site air secondary (manufacturer)
- device: Colorimetric Badge
manufacturer: K&M Environmental Products
model/type: SafeAir Arsine Monitor, part no. 382030-50
sampling information: 0.25 to 12-h exposure
upper measurement limit: 4.0 ppm for 0.25-h exposure
detection limit: 2.25 ppb for 8-h exposure
overall uncertainty: unknown
method reference: on-site air secondary (manufacturer)
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| Revised: 31 July 2003 |
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