Chemical Sampling Information
	Abietic Acid
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase ] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: Abietinic Acid; Sylvic Acid; Rosin Core Solder Pyrolysis Products OSHA IMIS Code Number: A616 Chemical Abstracts Service (CAS) Registry Number: 514-10-3 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: TP8580000 Chemical Description and Physical Properties: Yellow-orange crystalline powder. molecular formula: C20H30O2 molecular weight: 302.50 flash point: 187°C melting range: 172-175°C Health Factors Potential symptoms: Irritation of eyes, nose, and respiratory system; lacrimation; cough, chest tightness; nausea, vomiting; erythematovesicular dermatitis. Health Effects: Irritation – Eye, Nose, Throat---Marked (HE14); Asthma (HE9); Allergic contact dermatitis (HE3) Affected organs: Skin, respiratory system Notes: Abietic acid is a component of rosin from conifer (pine, fir, spruce) trees and may be found in solder flux, wood dust, paper products, and some wart-removing products, among others. Its biosynthetic pathway has been elucidated. Skin and respiratory sensitization may be due to hydroperoxy and epoxy oxidation products of abietic acid, rather than to abietic acid itself. Date Last Revised: 10/20/2006 Literature Basis: International Chemical Safety Cards (WHO/IPCS/ILO): Rosin. Berge, P.S., Harries, M.G., O’Brien, I. and Pepys, J.: Bronchial provocation studies in workers exposed to the fumes of electronic soldering fluxes. Clin. Allergy 10(2): 137-149, 1980. Estlander, T., Jolanki, R., Alanko, K. and Kanerva, L.: Occupational allergic contact dermatitis caused by wood dusts. Contact Dermatitis 44(4): 213-217, 2001. Funk, C. and Croteau, R.: Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis. Arch. Biochem. Biophys. 308(1): 258-266, 1994. Gäfvert, E., Shao, L.P., Karlberg, A.T., Nilsson, U. and Nilsson, J.L.: Contact allergy to resin acid hydroperoxides. Hapten binding via free radicals and epoxides. Chem. Res. Toxicol. 7(2): 260-266, 1994. Keira, T., et al.: Adverse effects of colophony. Ind. Health 35(1): 1-7, 1997. Sadhra, S., Foulds, I.S. and Gray, C.N.: Identification of contact allergens in unmodified rosin using a combination of patch testing and analytical chemistry techniques. Br. J. Dermatol. 134(4): 662-668, 1996. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Glass Fiber Filter (37 mm) analytical solvent: Methanol maximum volume: 200 Liters   maximum flow rate: 2.0 L/min current analytical method: High Performance Liquid Chromatography; HPLC/UV method reference: OSHA SLTC In-House File method classification: Not Validated analytical condition: Column: C18; Mobile Phase: 60:40:0.1 Acetonitrile: Water: Phosphoric acid; Detector Wavelength: 254nm All Trademarks are the property of their respective owners.