1-Bromopropane (1-BP) is a solvent that is used in degreasing, dry cleaning, spray adhesives, and aerosol solvents. Occupational exposure to 1-BP has been linked to neurological illnesses. Animal studies show that 1-BP may also cause cancer and reproductive disorders. Controls and personal protective equipment are available to protect workers from 1-BP exposure.
1-Bromopropane, also known as n-propyl bromide (nPB), is a solvent (CAS 106-94-5) with several commercial applications. Use of 1-BP has increased in workplaces over the past 20 years. 1-BP is often found in products used in:
Exposure to 1-BP can cause irritation (for example, of the eyes, mucous membranes, upper airways and skin) and can damage the nervous system. Neurologic effects can appear as headaches, dizziness, loss of consciousness, slurred speech, confusion, difficulty walking, muscle twitching, and/or loss of feeling in arms and legs [Ichihara et al. 2012]. These effects may continue among affected persons even after exposure to 1-BP has ended [Majersik et al. 2007].
As with many other solvents, workers can be exposed to 1-BP by breathing in vapor or mists of spray. Workers might also be exposed if the chemical touches their skin because it can be absorbed [Hanley et al. 2006; Frasch et al. 2011]. Additionally, the risk of health effects to workers increases the longer they work with or near 1-BP. Impacts on health have been seen in workers after exposures for as little as two days, although symptoms are more commonly associated with longer exposure [Ichihara et al. 2012].
Federal OSHA does not currently have a specific exposure standard for 1-BP; however, employers are required by law to keep their workers safe from this recognized hazard. Degreasing, spray adhesive, aerosol solvent and dry cleaning operations expose workers to air concentrations of 1-BP greater than the limits set by the California Occupational Safety and Health Administration (Cal-OSHA) and the American Conference of Governmental Industrial Hygienists (ACGIH). California has adopted a 5 ppm (parts per million) time-weighted average PEL (permissible exposure limit) along with a skin notation which means that a worker's skin, eyes, and mouth should be protected from any contact with 1-BP; this limit was based on reproductive and developmental toxicity (observed in animal studies) and technological feasibility assessments from industry [CA DIR 2009]. ACGIH currently recommends a 10 ppm time-weighted average threshold limit value but has proposed lowering the value to 0.1 ppm [ACGIH 2013].
Case Study Example [Majersik et al. 2007]
Six foam cushion gluers who were exposed to 1-BP vapors from spray adhesives were seen in a medical clinic for neurotoxicity. The workers had been employed at the facility from 3 months to 3 years. All patients complained of slow onset of lower extremity pain or numbness. Five of six complained of difficulty walking, and on examination had leg spasms, loss of sensation in limbs, and muscle twitching. Three patients initially had nausea and headache. Serum bromide concentrations and air samples were obtained to assess exposure. A seven hour time-weighted average air concentration of 1-BP was found to be 108 ppm (range 92-127 ppm). Two years after exposure, the two most severely affected patients still had trouble with walking and loss of feeling in their legs and they, along with a third patient, continued to feel pain most of the time.
Animal studies suggest that 1-BP exposure is associated with reduced blood cell counts and immunosuppression along with toxicity to the liver and reproductive and nervous systems. Furthermore, the National Toxicology Program (NTP) has classified 1-BP as reasonably anticipated to be a human carcinogen [NTP 2014]. This designation is based primarily on increased lung, large intestine and skin cancers seen in rodents that were exposed to 1-BP in the air [NTP 2011].
Under the Occupational Safety and Health Act of 1970, employers are responsible for providing safe and healthy working conditions for their workers.
OSHA's Hazard Communication standard (29 CFR 1910.1200) requires employers to give health and safety information and training to their workers who are potentially exposed to hazardous materials, including 1-BP. Employers must make available copies of Safety Data Sheets (SDS) for 1-BP and train workers to use them. 29 CFR 1910.1200(h). The SDS will note health hazards associated with all ingredients in the product. 29 CFR 1910.1200 App. D. The SDS will name 1-BP (or nPB) as an ingredient if it is present in the product at concentrations above 1%. 29 CFR 1910.1200 App. A.1.3.3. Employers must train workers on the health hazards and how to properly use equipment designed to reduce exposures. 29 CFR 1910.1200(h)(3). Employers must give training to workers in a manner and language that the worker understands. OSHA Directive CPL 02-02-038, Inspection Procedures for the Hazard Communication Standard, effective March 20, 1998; OSHA Standard 1910.1200(h) Interpretation Letter to Dr. Richard F. Andree, April 10, 1988.
NIOSH recommends that periodic "refresher" training be offered to workers exposed to hazardous materials in the workplace. The frequency and content of this recurrent training should be determined according to the needs of individual facilities, based on factors such as reports of health effects and changes in work practices and controls.
Workers reporting health effects after being exposed to 1-BP should be referred to a doctor or nurse with occupational or environmental medical expertise.
Doctors, nurses and other public health professionals should be aware of the types of health effects that may occur among workers exposed to 1-BP. A thorough occupational history should always be part of the clinical evaluation of persons who have unexplained symptoms or nonspecific neurologic symptoms that could be caused by one of several medical conditions or occupational exposures. Healthcare providers caring for workers with health effects related to occupational 1-BP exposure should report findings, and their significance, to the affected worker. These healthcare providers should also summarize results on potential work-related health effects, with personal identifiers removed, to the employers.
Evaluation of exposures in the workplace involves identification of potential hazards followed by characterization or estimates of the level of those hazards. Worker exposures to 1-BP in the air as well as through skin contact should be measured to determine whether the hazard needs to be controlled. Biological monitoring, such as measuring of 1-BP and its metabolites in the urine of exposed workers, may also be a useful tool to evaluate worker exposures. Many of the resources listed at the end of this document have information useful in evaluating worker exposures to 1-BP [Hanley et al. 2010; NIOSH 2002b].
Examples of Sampling Results:
Although exposures may not be found to exceed air concentration levels set by California or ACGIH at every workplace using 1-BP [NIOSH, 2000], overexposures have been found on many occasions. The table below reports selected studies where exposures measured were greater than the recommended levels.
|1-BP CONCENTRATIONS - FULL SHIFT MONITORING AT SELECTED WORKSITES|
|Operation||1-BP Concentration (Parts per million)*||Number of Samples||Notes|
[Hanley et al. 2010]
|Range 0.08 - 21||44||Workers near degreasers|
|Adhesive Spray Application
|Range 18-254||16||Foam cushion fabrication workers|
|Adhesive Spray Application
[Hanley et al. 2006]
|Range 45-200||26||Foam cushion fabrication workers: sprayers|
|Adhesive Spray Application
[Hanley et al. 2006]
|Range 0.6-60||34||Foam cushion fabrication workers: non-sprayers|
[Blando et al. 2010; NIOSH 2010]
[Blando et al. 2010; NIOSH 2010]
*ACGIH currently recommends a 10 parts per million (ppm) threshold limit value but has proposed lowering the value to 0.1 ppm [ACGIH 2013].
Some types of controls are preferred over others because they are more effective. Based on the principles of general industrial hygiene practice, the following types of controls (listed in order of preference) should be considered to control workplace exposures to 1-BP:
Elimination or Substitution
Eliminating the hazard of concern or substituting the hazardous substance with a less toxic/hazardous process material are the most effective ways to reduce exposures to a potentially hazardous substance. For example, an employer may be able to substitute water-based or acetone-based adhesives for 1-BP based adhesives. Replacement chemicals may also have associated hazards that need to be considered and controlled.
Engineering controls to reduce worker exposure to an airborne contaminant, preferably at the point where the contaminant gets into the air, or otherwise isolating the contaminant away from where workers are located, are effective means for reducing exposure. A variety of engineering controls may be considered:
Administrative controls are work practices and policies to reduce or prevent exposures to workplace hazards. The following administrative controls should be considered in workplaces using 1-BP:
Personal Protective Equipment (PPE)
PPE is used during the interim period when engineering controls are being installed or repaired, when engineering and administrative or work practice controls are not effective in adequately reducing exposure, or when controls are not feasible.
OSHA Consultations: OSHA's On-site Consultation Program offers free and confidential advice to small and medium-sized businesses in all states across the country, with priority given to high-hazard worksites. On-site Consultation services are independent of OSHA enforcement and do not result in penalties or citations. Consultants from state agencies or universities work with employers to identify workplace hazards, provide advice on compliance with OSHA standards, and assist in establishing safety and health management systems. To locate the OSHA On-site Consultation Program nearest you, call 1-800-321-6742 (OSHA) or visit www.osha.gov/dcsp/smallbusiness/index.html.
OSHA-Approved State Plans: Twenty-seven states and U.S. territories operate their own occupational safety and health state plan approved by OSHA. State plans have Hazard Communication standards that are at least as effective as OSHA's standards in providing protection to workers. A list of state plans and more information about each state plan's Hazard Communication standard is available at www.osha.gov/dcsp/osp/index.html.
OSHA Compliance Assistance: OSHA also has compliance assistance specialists throughout the nation who can provide general information about OSHA standards, short education programs on specific hazards or OSHA rights and responsibilities, and additional compliance assistance resources. Contact your local OSHA office for more information by calling 1-800-321-OSHA (6742) or visit OSHA's webpage.
NIOSH HHE Program: Employees, employee representatives, or employers can ask NIOSH to conduct Health Hazard Evaluations (HHEs) at their workplace. NIOSH may provide assistance and information by phone or in writing, or may visit the workplace to assess employee exposure and health. Based on their findings, NIOSH will recommend ways to reduce hazards and prevent work-related illness. The evaluation is done at no cost to the employees, employee representatives, or employers. For more information about the HHE Program, visit the NIOSH HHE webpage or contact the HHE program by phone at 513-841-4382. For general information or questions about any hazard or illness, call the NIOSH Information Service: 1-800-CDC-INFO (1-800-232-4636).
For questions or to get information or advice, to report an emergency, report a fatality or catastrophe, file a confidential complaint, order publications, or to request OSHA's free on-site consultation service, contact your nearest OSHA office, visit www.osha.gov, or call OSHA at 1-800-321-OSHA (6742), TTY 1-877-889-5627.
To receive documents or more information about occupational safety and health topics, contact NIOSH at 1-800-CDC-INFO (1-800-232-4636), TTY 1-888-232-6348, email email@example.com, or visit the NIOSH website at www.cdc.gov/niosh/.
Workers have the right to:
For more information, see OSHA's workers page.
This Hazard Alert is not a standard or regulation, and it creates no new legal obligations. It contains recommendations as well as descriptions of mandatory safety and health standards [and other regulatory requirements]. The recommendations are advisory in nature, informational in content, and are intended to assist employers in providing a safe and healthful workplace. The Occupational Safety and Health Act requires employers to comply with safety and health standards and regulations promulgated by OSHA or by a state with an OSHA-approved state plan. In addition, the Act's General Duty Clause, Section 5(a)(1), requires employers to provide their employees with a workplace free from recognized hazards likely to cause death or serious physical harm. The mention of any non-governmental organization or link to its website in this Hazard Alert does not constitute an endorsement by OSHA or NIOSH of that organization or its products, services, or website.
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DHHS (NIOSH) Publication 2013-150 OSHA - HA-3676-2013
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