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Synonyms: Methylstyrene; Tolyethylene; ortho, meta & para-vinyltoluene (mixed isomers)
OSHA IMIS Code Number: 2582
Chemical Abstracts Service (CAS) Registry Number: 25013-15-4
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: WL5075000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2618 130P
NIOSH Pocket Guide to Chemical Hazards, Vinyl toluene: chemical description, physical properties, potentially hazardous incompatibilities, and more
OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Z-1 Table -- 100 ppm, 480 mg/m3 TWA
Construction Industry: 29 CFR 1926.55 Appendix A -- 100 ppm, 480 mg/m3 TWA
Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 100 ppm, 480 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 50 ppm, 242 mg/m3 TWA; 100 ppm, 483 mg/m3 STEL; Appendix A4 - Not Classifiable as a Human Carcinogen
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 100 ppm, 480 mg/m3 TWA
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 400 ppm
Potential Symptoms: Irritation of eyes, skin, upper respiratory system; sore throat; headache; dizziness, drowsiness; dermatitis; in animals: narcosis; INGES. ACUTE: Abdominal pain, nausea, vomiting.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); CNS effects (HE7)
Affected Organs: Eyes, skin, respiratory system, CNS
- Above 54°C, explosive vapor/air mixtures may be formed.
- Vinyl toluene is a methyl derivative of styrene and shows a profile of urinary metabolites in rats similar to that of styrene. In humans, major enzymes involved in the metabolism of styrene include cytochrome P450s 2E1 and 2B6, epoxide hydrolase 1, and glutathione S-transferases M1, T1, and P1.
- Chronic inhalational studies by NTP in rats (100 or 300 ppm) and mice (10 or 25 ppm) noted bronchitis and inflammatory lesions of the nasal mucosa, but no carcinogenic activity of vinyl toluene.
- Significant decreases (14-19%) in the neurotransmitter dopamine and increases (19-35%) in its metabolite, homovanillic acid, were reported for two brain areas of rabbits 12 hours after a 12-hr inhalational exposure to 750 ppm vinyl toluene. This concentration, however, is nearly double NIOSH's IDLH for vinyl toluene.
- NIOSH Pocket Guide to Chemical Hazards: Vinyl toluene.
- International Chemical Safety Cards (WHO/IPCS/ILO): Vinyl toluene.
- Ma, M., et al.: Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene. Toxicol. Lett. 160(1): 84-91, 2005.
- National Toxicology Program: NTP toxicology and carcinogenesis studies of vinyl toluene (mixed isomers) (65%-71% meta-isomer and 32-35% para-isomer) (CAS No. 25013-15-4) in F344/N rats and BeC3F1 mice (inhalation studies). Natl. Toxicol. Program Tech. Rep. Ser. 375: 1-191, 1990.
- No authors listed: Vinyl toluene. IARC Monogr. Eval. Carcinog. Risks Hum. 60: 373-388, 1994.
- Pohanish, R.P. (editor): Vinyl Toluene. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2333-2335.
- Romanelli, A., Falzoi, M., Mutti, A., Bergamaschi, E. and Franchini, I.: Effects of some monocyclic aromatic solvents and their metabolites on brain dopamine in rabbits. J. Appl. Toxicol. 6(6): 431-436, 1986.
Date Last Revised: 06/29/2006
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Carbon Disulfide
maximum volume: 30 Liters
maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 1501 [135 KB PDF, 7 pages])
method classification: Partially Validated
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