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1,3,5-Triglycidyl Isocyanurate

General Description

Synonyms: TGIC; Triglycidyl isocyanurate; 1,3,5-Triglycidyl-s-triazinetrione; TGT; Glycidyl isocyanurate; Tris(epoxypropyl)isocyanurate; s-Triazine-2,4,6(1H,3H,5H)-trione; 1,3,5-tris(2,3-epoxypropyl)-s-Triazine-2,4,6(1H,3H,5H)-trione [1,3,5-triglycidyl isocyanurate (TGIC) has two stereoisomers, α and ß]

OSHA IMIS code: T405

CAS number: 2451-62-9

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method:
  • glass fiber filter (37 mm) coated with hydrobromic acid
  • maximum volume: 60 L
  • maximum flow rate: 1.0 L/min
  • current analytical method: gas chromatography; GC/ECD
  • method reference: OSHA PV2055 (partially validated)
  • note: OSHA personnel may obtain coated filters from the OSHA-Salt Lake Technical Center.

Exposure Limits and Health Effects (Updated September 6, 2012)

Standard Set By Exposure Limit Health Effect Codes -- Health Effects and Target Organs
OSHA PEL Not established
NIOSH REL Not established
ACGIH TLV® (1994) 0.05 mg/m3 TWA HE12 -- hematologic effects (leukopenia, thrombocytopenia, platelet suppression, myelosuppression)
HE5 -- male reproductive damage
CAL/OSHA PELs 0.005 mg/m3 TWA  

Carcinogenic classification:

  • NTP: Not listed
  • IARC: Not listed
  • EPA: Not listed

EPA Inhalation Reference Concentration (RfC): Not established

ATSDR Inhalation Minimal Risk Levels (MRLs): Not established

NIOSH IDLH concentration: Not established

Notes on other potential health effects and hazards:

  1. A 2003 publication mentioned anecdotal complaints of testicular atrophy in men and menstrual irregularities in women exposed to TGIC during powder paint coating work. However, no medical data to support these claims were provided (Allmaras 2003).
  2. The substance may cause effects on the central nervous system, kidneys, liver, lungs and gastrointestinal tract, resulting in tissue lesions (NIOSH/IPCS 2001).
  3. TGIC forms adducts with DNA and has tested positive in mutagenicity/genotoxicity tests (Lindell and Montelius 2001).
  4. Allergic contact dermatitis has been reported in several case studies of occupational exposure to triglycidyl isocyanurate (ACGIH 2001; WHO 1998).
  5. Occupational asthma has been reported in several case studies of exposure to triglycidyl isocyanurate (Anees et al. 2011; Meuleman et al. 1999; Piirilä et al. 1997; Sastre et al. 2011).

Partial reference list:

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 1,3,5-Triglycidyl-s-triazinetrione. 2016.
  • Allmaras, S.: Worker exposure to 1,3,5-tryglycidyl isocyanurate (TGIC) in powder paint coating operations. Appl. Occup. Environ. Hyg. 18(3):151-153, 2003.
  • Anees W, Moore VC, Croft JS, Robertson AS, Burge PS: Occupational asthma caused by heated triglycidyl isocyanurate. Occup Med (Lond) 61(1):65-7, Jan 2011.
  • Lindell, B. and Montelius, J: Triglycidyl isocyanurate. Arbete och Hälsa 18: 1-30, 2001.
  • Meuleman L, Goossens A, Linders C, Rochette F, Nemery B: Sensitization to triglycidylisocyanurate (TGIC) with cutaneous and respiratory manifestations. Allergy 54(7):752-6, July 1999.
  • NIOSH/CEC/IPCS: International Chemical Safety Cards - Triglycidyl Isocyanurate. 2001.
  • Piirilä P, Estlander T, Keskinen H, Jolanki R, Laakkonen A, Pfäffli P, Tupasela O, Tuppurainen M, Nordman H.Occupational asthma caused by triglycidyl isocyanurate (TGIC). Clin Exp Allergy 27(5):510-4, May 1997.
  • Sastre J, Carnes J, García del Potro M, Manso L, Aguado E, Fernández-Nieto M: Occupational asthma caused by triglycidyl isocyanurate. Int Arch Occup Environ Health. 84(5):547-9, June 2011.
  • World Health Organization (WHO): Triglycidyl Isocyanurate. 1998.

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