<< Back to Chemical Sampling Information

Chemical Sampling Information (CSI)
Search (use word(s)/phrase)
Table of Contents
By Name
A B C D E F G H I J K L M
N O P Q R S T U V W X Y Z

By CAS Number
Quick Links

General Description

Synonyms: TGIC; Triglycidyl isocyanurate; 1,3,5-Triglycidyl-s-triazinetrione; TGT; Glycidyl isocyanurate; Tris(epoxypropyl)isocyanurate; s-Triazine-2,4,6(1H,3H,5H)-trione; 1,3,5-tris(2,3-epoxypropyl)-s-Triazine-2,4,6(1H,3H,5H)-trione
[1,3,5-triglycidyl isocyanurate (TGIC) has two stereoisomers, α and ß]

OSHA IMIS Code Number: T405

Chemical Abstracts Service (CAS) Registry Number: 2451-62-9

NIOSH Registry of Toxic Effects (RTECS) Identification Number: XZ1994900

IPCS International Chemical Safety Card - Triglycidyl Isocyanurate: Acute hazards, symptoms, physical and chemical dangers, physical properties, and more




Exposure Limits and Health Effects

Exposure Limit

Limit Values

HE Codes

Health Factors and Target Organs

OSHA Permissible Exposure Limit (PEL)

Not established

 

 

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL)

Not established

 

 

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) (2001)
(TLV listed under 1,3,5-Triglycidyl-s-triazinetrione)

0.05 mg/m3
TWA

H12

Hematopoietic effects (leukopenia, thrombocytopenia, platelet suppression, myelosuppression)

HE5

Male reproductive damage

CAL/OSHA PEL

0.005 mg/m3TWA

 

 

National Toxicology Program (NTP) carcinogenic classification: Not listed

International Agency for Research on Cancer (IARC) carcinogenic classification: Not listed

U.S. Environmental Protection Agency (EPA) carcinogenic classification: Not listed

EPA Inhalation Reference Concentration (RfC): Not established

Agency for Toxic Substances and Disease Registry (ATSDR) Inhalation Minimal Risk Level (MRL): Not established

NIOSH Immediately Dangerous to Life or Health (IDLH) concentration: Not established

Notes on Other Potential Health Effects and Hazards

  1. A 2003 publication mentioned anecdotal complaints of testicular atrophy in men and menstrual irregularities in women exposed to TGIC during powder paint coating work. However, no medical data to support these claims were provided (Allmaras 2003).
  2. The substance may cause effects on the central nervous system, kidneys, liver, lungs and gastrointestinal tract, resulting in tissue lesions (NIOSH/IPCS 2001).
  3. TGIC forms adducts with DNA and has tested positive in mutagenicity/genotoxicity tests (Lindell and Montelius 2001).
  4. Allergic contact dermatitis has been reported in several case studies of occupational exposure to triglycidyl isocyanurate (ACGIH 2001; WHO 1998).
  5. Occupational asthma has been reported in several case studies of exposure to triglycidyl isocyanurate (Anees et al. 2011; Meuleman et al. 1999; Piirilä et al. 1997; Sastre et al. 2011).

Date Last Revised: 9/6/2012

Literature Basis

  • ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - 1,3,5-Triglycidyl-s-triazinetrione. 2001.
  • Allmaras, S.: Worker exposure to 1,3,5-tryglycidyl isocyanurate (TGIC) in powder paint coating operations. Appl. Occup. Environ. Hyg. 18(3): 151-153, 2003.
  • Anees W, Moore VC, Croft JS, Robertson AS, Burge PS: Occupational asthma caused by heated triglycidyl isocyanurate. Occup Med (Lond) 61(1):65-7, Jan 2011.
  • Lindell, B. and Montelius, J: Triglycidyl isocyanurate [114 KB PDF, 36 pages]. Arbete och Hälsa 18: 1-30, 2001.
  • Meuleman L, Goossens A, Linders C, Rochette F, Nemery B: Sensitization to triglycidylisocyanurate (TGIC) with cutaneous and respiratory manifestations. Allergy 54(7):752-6, July 1999.
  • NIOSH/IPCS: International Chemical Safety Cards - Triglycidyl Isocyanurate. 2001.
  • Piirilä P, Estlander T, Keskinen H, Jolanki R, Laakkonen A, Pfäffli P, Tupasela O, Tuppurainen M, Nordman H.Occupational asthma caused by triglycidyl isocyanurate (TGIC). Clin Exp Allergy 27(5):510-4, May 1997.
  • Sastre J, Carnes J, García del Potro M, Manso L, Aguado E, Fernández-Nieto M: Occupational asthma caused by triglycidyl isocyanurate. Int Arch Occup Environ Health. 84(5):547-9, Jun 2011.
  • World Health Organization (WHO): Triglycidyl Isocyanurate. 1998.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:

  • sampling media: Coated Glass Fiber Filter (37 mm) Coated with Hydrobromic Acid
    maximum volume: 60 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: Gas Chromatography; GC/ECD
    method reference: OSHA Analytical Method (OSHA PV2055)
    method classification: Partially Validated
    note: OSHA personnel may obtain coated filters from SLTC.

** All Trademarks are the property of their respective owners.


Accessibility Assistance: Contact the OSHA Directorate of Technical Support and Emergency Management at (202) 693-2300 for assistance accessing PDF materials.