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Chemical Sampling Information (CSI)
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General Description

Synonyms: diethylaminoethane; N,N-diethylaminoethane; TEA

OSHA IMIS Code Number: 2480

Chemical Abstracts Service (CAS) Registry Number: 121-44-8

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: YE0175000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1296 132

NIOSH Pocket Guide to Chemical Hazards, Triethylamine: chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 25 ppm, 100 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A -- 25 ppm, 100 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 25 ppm, 100 mg/m3 TWA

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1 ppm, 4.1 mg/m3 TWA; 3 ppm, 12.4 mg/m3 STEL; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix D - Substances With No Established RELs

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 200 ppm

Potential Symptoms: Irritation of eyes, skin, respiratory system; mild headache, dizziness, weakness, nausea; cough, sore throat, shortness of breath, pulmonary edema (may be delayed); redness, pain, burns in skin and eyes; in animals: myocardial, kidney, liver damage; INGES. ACUTE: Abdominal pain, burning sensation; collapse or shock.

Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Lung edema (HE11); Corneal damage (HE3).

Affected Organs: Eyes, skin, respiratory system, cardiovascular system, liver, kidneys

Notes:

  1. Vapor/air mixtures of triethylamine may be explosive.
  2. In human volunteers, a 4-hour exposure to 1.6 ppm caused blurred vision (glaucopsia) and a decrease in contrast sensitivity in some subjects, whereas a 4-hr exposure to 0.7 ppm was reported to have no significant effect on vision.
  3. The pharmacokinetics of triethylamine and its major metabolite, triethylamine-N-oxide have been studied after inhalational, oral and intravenous administration to human volunteers. Both are eliminated in the urine, with mean half-lives in the range of 2.8 to 3.7 hours.
Date Last Revised: 05/03/2006

Literature Basis:
  • NIOSH Pocket Guide to Chemical Hazards: Triethylamine.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Triethylamine.
  • kesson, B., Skerfving, S. and Mattiasson, L.: Experimental study on the metabolism of triethylamine in man. Br. J. Ind. Med.. 45(4): 262-268, 1988.
  • kesson, B., Vinge, E. and Skerfving, S.: Pharmacokinetics of triethylamine and triethylamine-n-oxide in man. Toxicol. Appl. Pharmacol. 100(3): 529-538, 1989.
  • Ballantyne, B.: Glaucopsia: an occupational ophthalmic hazard. Toxicol. Rev. 23(2): 83-90, 2004.
  • Jrvinen, P.: Headache and blood pressure among triethylamine-exposed foundry workers. Occup. Med. (Lond.) 48(2): 113-117, 1998.
  • Jrvinen, P., Engstrm, K., Riihimki, V., Ruusuvaara, P. and Setl, K.: Effects of experimental exposure to triethylamine on vision and the eyes. Occup. Environ. Med. 56(1): 1-5, 1999.
  • Pohanish, R.P. (editor): Triethylamine. In, Sittigs Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 2267-2269.
Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: Coated XAD-7 Tube (80/40 mg sections) Coating is 10% Phosphoric Acid.
    analytical solvent: (50:50) Methanol:Deionized Water
    maximum volume: 20 Liters
    maximum flow rate: 0.2 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA PV2060)
    method classification: Partially Validated

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