<< Back to Chemical Sampling Information

Chemical Sampling Information (CSI)
Search (use word(s)/phrase)
Table of Contents
By Name
A B C D E F G H I J K L M
N O P Q R S T U V W X Y Z

By CAS Number
Quick Links

General Description

Synonyms: Tris(2-hydroxyethyl)amine; Tri(hydroxyethyl)amine; Trolamine; TEA (amino alcohol); Nitrilo-2,2',2''-Triethanol; Triethylolamine; Daltogen

OSHA IMIS Code Number: T185

Chemical Abstracts Service (CAS) Registry Number: 102-71-6

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KL9275000

Chemical Description and Physical Properties:

clear, colorless, viscous, hygroscopic liquid with slight ammoniacal odor
molecular weight: 149.22
molecular formula: C6H15NO3
flash point: 179°C

Exposure Limits

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA

Health Factors

Potential Symptoms: Irritation of eyes, skin, respiratory tract; cough, sore throat; asthma; allergic contact dermatitis (not common)

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Respiratory sensitization (asthma) (HE9); Dermatitis (HE3)

Affected Organs: Eyes, skin, respiratory system

Notes:

  1. OSHA does not have a PEL for triethanolamine.
  2. Studies with mice indicate extensive absorption through the skin.
  3. Cases of asthma occurred after several years' exposure to heated or vaporized triethanolamine, as in metal-working fluids.
  4. Two-year dermal application studies with female B6C3F1 mice (100, 300, 1000 mg/kg, 5 days per week) indicated some evidence of carcinogenic activity based on increased incidences of hepatocellular adenoma. A proposed mechanism for this is the production of a deficiency of choline.

Literature Basis:

  • International Chemical Safety Cards (WHO/IPCS/ILO): Triethanolamine.
  • NIOSH Registry of Toxic Effects of Chemical Substances, RTECS #: KL9275000: Ethanol, 2,2',2"- nitrilotri-.
  • Blum, A. and Lischka, G.: Allergic contact dermatitis from mono-, di- and triethanolamine. Contact Dermatitis 36(3): 166, 1997.
  • National Toxicology Program: NTP toxicology and carcinogenesis studies of triethanolamine (Cas No. 102-71-6) in B6C3F1 mice (dermal studies). Nat. Toxicol. Program Tech. Rep. Ser. (518): 5-163, 2004.
  • Pohanish, R.P. (editor): Ethanolamines. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1028-1031.
  • Savonius, B, Keskinen, H., Tuppurainen, M. and Kanerva, L.: Occupational asthma caused by ethanolamines. Allergy 49(10): 877-881, 1994.
  • Stott, W.T., Radtke, B.J., Linscombe, V.A., Mar, M.-H. and Zeisel, S.H.: Evaluation of the potential of triethanolamine to alter hepatic choline levels in female B6C3F1 mice. Toxicol. Sci. 79(2): 242-247, 2004.
  • Stott, W.T., Waechter, J.M., Rick, D.L. and Mendrala, A.L.: Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice. Food Chem. Toxicol. 38(11): 1043-1051, 2000.

Date Last Revised: 08/17/2004

Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: 37 mm Glass Fiber Filter
    analytical solvent: Acetone
    maximum volume: 100 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: Gas Chromatography; GC/FID
    method reference: OSHA Analytical Method (OSHA PV2141)
    method classification: Partially Validated

** All Trademarks are the property of their respective owners.